Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging
Liu, MM; Li, Q; Liang, L; Li, J; Wang, K; Li, JJ; Lv, M; Chen, N; Song, HY; Lee, J; Shi, JY; Wang, LH; Lal, R; Fan, CH
2017
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号8期号:-页码:-
文章类型期刊论文
摘要Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate their cellular uptake and transport. Significantly, even single nanoparticles could cluster intracellularly, yet their clustering state and subsequent trafficking are not well understood. Here, we used DNA-decorated gold (fPlas-gold) nanoparticles as a dually emissive fluorescent and plasmonic probe to examine their clustering states and intracellular transport. Evidence from correlative fluorescence and plasmonic imaging shows that endocytosis of fPlas-gold follows multiple pathways. In the early stages of endocytosis, fPlas-gold nanoparticles appear mostly as single particles and they cluster during the vesicular transport and maturation. The speed of encapsulated fPlas-gold transport was critically dependent on the size of clusters but not on the types of organelle such as endosomes and lysosomes. Our results provide key strategies for engineering theranostic nanocarriers for efficient health management.
关键词Clathrin-mediated Endocytosis Cell Mechanisms Microscopy Endosomes Dynamics Platform Motors Cancer Virus
DOI10.1038/ncomms15646
关键词[WOS]CLATHRIN-MEDIATED ENDOCYTOSIS ; CELL ; MECHANISMS ; MICROSCOPY ; ENDOSOMES ; DYNAMICS ; PLATFORM ; MOTORS ; CANCER ; VIRUS
收录类别SCI
语种英语
WOS记录号WOS:000402395100001
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28796
专题中科院上海应用物理研究所2011-2018年
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GB/T 7714
Liu, MM,Li, Q,Liang, L,et al. Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging[J]. NATURE COMMUNICATIONS,2017,8(-):-.
APA Liu, MM.,Li, Q.,Liang, L.,Li, J.,Wang, K.,...&Fan, CH.(2017).Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging.NATURE COMMUNICATIONS,8(-),-.
MLA Liu, MM,et al."Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging".NATURE COMMUNICATIONS 8.-(2017):-.
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