Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats
Liu, HQ; Zhang, CS; Fan, XX; Duan, YN; Xiao, TQ; Du, GH; Fu, YN; Liu, HG; Wen, H
2017
发表期刊PLOS ONE
ISSN1932-6203
卷号12期号:9页码:-
文章类型期刊论文
摘要Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages. We quantitatively analyzed and evaluated the different pathological characterizations of hepatic echinococcosis during the development of this disease via our PAD-based PPCT and especially provided evidence that hepatic alveolar echinococcosis invades the liver tissue and spreads through blood flow systems with abundant blood supply in the early stage. Additionally, the infiltration of tiny vesicles in HE lesions can be clearly observed by our PAD-PPCT technique due to the striking contrast-to-noise ratio (CNR) and mass density resolution, which cannot be found by the medical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound, in hospitals. The results demonstrated that our PAD-PPCT technique has a great potential for indicating the subtle structural information of pathological changes in soft biomedical specimens, especially helpful for the research of early micromorphology of diseases.
关键词Alveolar Echinococcosis Contrast Tomography Attenuation Duality Fresnel Region Microtomography Holotomography Optimization Ultrasound Liver Image
DOI10.1371/journal.pone.0183396
关键词[WOS]ALVEOLAR ECHINOCOCCOSIS ; CONTRAST TOMOGRAPHY ; ATTENUATION DUALITY ; FRESNEL REGION ; MICROTOMOGRAPHY ; HOLOTOMOGRAPHY ; OPTIMIZATION ; ULTRASOUND ; LIVER ; IMAGE
收录类别SCI
语种英语
WOS记录号WOS:000410001100020
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28807
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
GB/T 7714
Liu, HQ,Zhang, CS,Fan, XX,et al. Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats[J]. PLOS ONE,2017,12(9):-.
APA Liu, HQ.,Zhang, CS.,Fan, XX.,Duan, YN.,Xiao, TQ.,...&Wen, H.(2017).Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats.PLOS ONE,12(9),-.
MLA Liu, HQ,et al."Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats".PLOS ONE 12.9(2017):-.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Robust phase-retriev(12953KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, HQ]的文章
[Zhang, CS]的文章
[Fan, XX]的文章
百度学术
百度学术中相似的文章
[Liu, HQ]的文章
[Zhang, CS]的文章
[Fan, XX]的文章
必应学术
必应学术中相似的文章
[Liu, HQ]的文章
[Zhang, CS]的文章
[Fan, XX]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。