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Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats
Liu, HQ; Zhang, CS; Fan, XX; Duan, YN; Xiao, TQ; Du, GH; Fu, YN; Liu, HG; Wen, H
2017
Source PublicationPLOS ONE
ISSN1932-6203
Volume12Issue:9Pages:-
Subtype期刊论文
AbstractPropagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages. We quantitatively analyzed and evaluated the different pathological characterizations of hepatic echinococcosis during the development of this disease via our PAD-based PPCT and especially provided evidence that hepatic alveolar echinococcosis invades the liver tissue and spreads through blood flow systems with abundant blood supply in the early stage. Additionally, the infiltration of tiny vesicles in HE lesions can be clearly observed by our PAD-PPCT technique due to the striking contrast-to-noise ratio (CNR) and mass density resolution, which cannot be found by the medical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound, in hospitals. The results demonstrated that our PAD-PPCT technique has a great potential for indicating the subtle structural information of pathological changes in soft biomedical specimens, especially helpful for the research of early micromorphology of diseases.
KeywordAlveolar Echinococcosis Contrast Tomography Attenuation Duality Fresnel Region Microtomography Holotomography Optimization Ultrasound Liver Image
DOI10.1371/journal.pone.0183396
WOS KeywordALVEOLAR ECHINOCOCCOSIS ; CONTRAST TOMOGRAPHY ; ATTENUATION DUALITY ; FRESNEL REGION ; MICROTOMOGRAPHY ; HOLOTOMOGRAPHY ; OPTIMIZATION ; ULTRASOUND ; LIVER ; IMAGE
Indexed BySCI
Language英语
WOS IDWOS:000410001100020
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28807
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Liu, HQ,Zhang, CS,Fan, XX,et al. Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats[J]. PLOS ONE,2017,12(9):-.
APA Liu, HQ.,Zhang, CS.,Fan, XX.,Duan, YN.,Xiao, TQ.,...&Wen, H.(2017).Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats.PLOS ONE,12(9),-.
MLA Liu, HQ,et al."Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats".PLOS ONE 12.9(2017):-.
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