Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats

doi:10.1371/journal.pone.0183396

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats
	Liu, HQ; Zhang, CS; Fan, XX; Duan, YN; Xiao, TQ; Du, GH; Fu, YN; Liu, HG; Wen, H
	2017
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	12 期号:9 页码:-
文章类型	期刊论文
摘要	Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages. We quantitatively analyzed and evaluated the different pathological characterizations of hepatic echinococcosis during the development of this disease via our PAD-based PPCT and especially provided evidence that hepatic alveolar echinococcosis invades the liver tissue and spreads through blood flow systems with abundant blood supply in the early stage. Additionally, the infiltration of tiny vesicles in HE lesions can be clearly observed by our PAD-PPCT technique due to the striking contrast-to-noise ratio (CNR) and mass density resolution, which cannot be found by the medical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound, in hospitals. The results demonstrated that our PAD-PPCT technique has a great potential for indicating the subtle structural information of pathological changes in soft biomedical specimens, especially helpful for the research of early micromorphology of diseases.
关键词	Alveolar Echinococcosis Contrast Tomography Attenuation Duality Fresnel Region Microtomography Holotomography Optimization Ultrasound Liver Image
DOI	10.1371/journal.pone.0183396
关键词[WOS]	ALVEOLAR ECHINOCOCCOSIS ; CONTRAST TOMOGRAPHY ; ATTENUATION DUALITY ; FRESNEL REGION ; MICROTOMOGRAPHY ; HOLOTOMOGRAPHY ; OPTIMIZATION ; ULTRASOUND ; LIVER ; IMAGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000410001100020
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28807
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Liu, HQ,Zhang, CS,Fan, XX,et al. Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats[J]. PLOS ONE,2017,12(9):-.
APA	Liu, HQ.,Zhang, CS.,Fan, XX.,Duan, YN.,Xiao, TQ.,...&Wen, H.(2017).Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats.PLOS ONE,12(9),-.
MLA	Liu, HQ,et al."Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats".PLOS ONE 12.9(2017):-.

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