Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking
Zhang, KY; Feng, Q; Xu, JB; Xu, XY; Tian, F; Yeung, KWK; Bian, LM
2017
发表期刊ADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
卷号27期号:34页码:-
文章类型期刊论文
摘要Nanocomposite hydrogels consist of a polymer matrix embedded with nanoparticles (NPs), which provide the hydrogels with unique bioactivities and mechanical properties. Incorporation of NPs via in situ precipitation in the polymer matrix further enhances these desirable hydrogel properties. However, the noncytocompatible pH, osmolality, and lengthy duration typically required for such in situ precipitation strategies preclude cell encapsulation in the resultant hydrogels. Bisphosphonate (BP) exhibits a variety of specific bioactivities and excellent binding affinity to multivalent cations such as magnesium ions (Mg2+). Here, the preparation of nanocomposite hydrogels via self-assembly driven by bisphosphonate-Mg2+ coordination is described. Upon mixing solutions of polymer bearing BPs, BP monomer (Ac-BP), and Mg2+, this effective and dynamic coordination leads to the rapid self-assembly of Ac-BP-Mg NPs which function as multivalent crosslinkers stabilize the resultant hydrogel structure at physiological pH. The obtained nanocomposite hydrogels are self-healing and exhibit improved mechanical properties compared to hydrogels prepared by blending prefabricated NPs. Importantly, the hydrogels in this study allow the encapsulation of cells and subsequent injection without compromising the viability of seeded cells. Furthermore, the acrylate groups on the surface of Ac-BP-Mg NPs enable facile temporal control over the stiffness and crosslinking density of hydrogels via UV-induced secondary crosslinking, and it is found that the delayed introduction of this secondary crosslinking enhances cell spreading and osteogenesis.
关键词Calcium-phosphate Nanoparticles In-situ Regenerative Medicine Osteogenic Differentiation Orthopedic Implants Tissue Regeneration Graphene Oxide Bone Hydroxyapatite Hyaluronan
DOI10.1002/adfm.201701642
关键词[WOS]CALCIUM-PHOSPHATE NANOPARTICLES ; IN-SITU ; REGENERATIVE MEDICINE ; OSTEOGENIC DIFFERENTIATION ; ORTHOPEDIC IMPLANTS ; TISSUE REGENERATION ; GRAPHENE OXIDE ; BONE ; HYDROXYAPATITE ; HYALURONAN
收录类别SCI
语种英语
WOS记录号WOS:000410162200005
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28811
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
GB/T 7714
Zhang, KY,Feng, Q,Xu, JB,et al. Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(34):-.
APA Zhang, KY.,Feng, Q.,Xu, JB.,Xu, XY.,Tian, F.,...&Bian, LM.(2017).Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking.ADVANCED FUNCTIONAL MATERIALS,27(34),-.
MLA Zhang, KY,et al."Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking".ADVANCED FUNCTIONAL MATERIALS 27.34(2017):-.
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