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Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking
Zhang, KY; Feng, Q; Xu, JB; Xu, XY; Tian, F; Yeung, KWK; Bian, LM
2017
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume27Issue:34Pages:-
Subtype期刊论文
AbstractNanocomposite hydrogels consist of a polymer matrix embedded with nanoparticles (NPs), which provide the hydrogels with unique bioactivities and mechanical properties. Incorporation of NPs via in situ precipitation in the polymer matrix further enhances these desirable hydrogel properties. However, the noncytocompatible pH, osmolality, and lengthy duration typically required for such in situ precipitation strategies preclude cell encapsulation in the resultant hydrogels. Bisphosphonate (BP) exhibits a variety of specific bioactivities and excellent binding affinity to multivalent cations such as magnesium ions (Mg2+). Here, the preparation of nanocomposite hydrogels via self-assembly driven by bisphosphonate-Mg2+ coordination is described. Upon mixing solutions of polymer bearing BPs, BP monomer (Ac-BP), and Mg2+, this effective and dynamic coordination leads to the rapid self-assembly of Ac-BP-Mg NPs which function as multivalent crosslinkers stabilize the resultant hydrogel structure at physiological pH. The obtained nanocomposite hydrogels are self-healing and exhibit improved mechanical properties compared to hydrogels prepared by blending prefabricated NPs. Importantly, the hydrogels in this study allow the encapsulation of cells and subsequent injection without compromising the viability of seeded cells. Furthermore, the acrylate groups on the surface of Ac-BP-Mg NPs enable facile temporal control over the stiffness and crosslinking density of hydrogels via UV-induced secondary crosslinking, and it is found that the delayed introduction of this secondary crosslinking enhances cell spreading and osteogenesis.
KeywordCalcium-phosphate Nanoparticles In-situ Regenerative Medicine Osteogenic Differentiation Orthopedic Implants Tissue Regeneration Graphene Oxide Bone Hydroxyapatite Hyaluronan
DOI10.1002/adfm.201701642
Indexed BySCI
WOS KeywordCALCIUM-PHOSPHATE NANOPARTICLES ; IN-SITU ; REGENERATIVE MEDICINE ; OSTEOGENIC DIFFERENTIATION ; ORTHOPEDIC IMPLANTS ; TISSUE REGENERATION ; GRAPHENE OXIDE ; BONE ; HYDROXYAPATITE ; HYALURONAN
Language英语
WOS IDWOS:000410162200005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28811
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang, KY,Feng, Q,Xu, JB,et al. Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(34):-.
APA Zhang, KY.,Feng, Q.,Xu, JB.,Xu, XY.,Tian, F.,...&Bian, LM.(2017).Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking.ADVANCED FUNCTIONAL MATERIALS,27(34),-.
MLA Zhang, KY,et al."Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking".ADVANCED FUNCTIONAL MATERIALS 27.34(2017):-.
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