CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography
Wang, LP; Mu, ZH; Lin, XJ; Geng, JL; Xiao, TQ; Zhang, ZJ; Wang, YT; Guan, YJ; Yang, GY
2017
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
Volume9Issue:-Pages:-
Subtype期刊论文
AbstractHypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dynamic changes of vascular structure in hypertensive rats using novel synchrotron radiation angiography. Twenty-four spontaneously hypertensive rats (SHR) and 24 Sprague-Dawley (SD) rats underwent synchrotron radiation (SR) angiography. Each group had 8 animals. We studied the cerebral vascular changes in SHR over a time period of 3-12-month and performed quantitative analysis. No vascular morphology differences between SHR and SD rats were observed in the early stage of hypertension. The number of twisted blood vessels in the front brain significantly increased at the 9-and 12-month observation time-points in the SHR compared to the SD rats (p < 0.01). The vessel density of the cortex and the striatum in SHR was consistently higher than that in SD rats at time points of 3-, 9-, and 12-month (p < 0.001). Vascular elasticity decreased both in SHR and SD rats with aging. There were statistically significant differences in the relative vascular elasticity of extracranial/intracranial internal carotid artery, middle cerebral artery, posterior cerebral artery and anterior cerebral artery between SHR and SD rats at 12-month (p < 0.01). We concluded that the dynamic vascular alterations detected by SR angiography provided novel imaging data for the study of hypertension in vivo. The longer the course of hypertension was, the more obvious the vascular differences between the SHR and the SD rats became.
KeywordCerebral-artery Occlusion Blood-brain-barrier Magnetic-resonance Angiography Acute Ischemic-stroke In-vivo Collateral Circulation Mr-angiography Lifetime Risk Model Angiogenesis
DOI10.3389/fnagi.2017.00359
WOS KeywordCEREBRAL-ARTERY OCCLUSION ; BLOOD-BRAIN-BARRIER ; MAGNETIC-RESONANCE ANGIOGRAPHY ; ACUTE ISCHEMIC-STROKE ; IN-VIVO ; COLLATERAL CIRCULATION ; MR-ANGIOGRAPHY ; LIFETIME RISK ; MODEL ; ANGIOGENESIS
Indexed BySCI
Language英语
WOS IDWOS:000414263300001
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28817
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Wang, LP,Mu, ZH,Lin, XJ,et al. Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography[J]. FRONTIERS IN AGING NEUROSCIENCE,2017,9(-):-.
APA Wang, LP.,Mu, ZH.,Lin, XJ.,Geng, JL.,Xiao, TQ.,...&Yang, GY.(2017).Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.FRONTIERS IN AGING NEUROSCIENCE,9(-),-.
MLA Wang, LP,et al."Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography".FRONTIERS IN AGING NEUROSCIENCE 9.-(2017):-.
Files in This Item: Download All
File Name/Size DocType Version Access License
Simultaneous Imaging(2576KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, LP]'s Articles
[Mu, ZH]'s Articles
[Lin, XJ]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, LP]'s Articles
[Mu, ZH]'s Articles
[Lin, XJ]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, LP]'s Articles
[Mu, ZH]'s Articles
[Lin, XJ]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.