Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography
Wang, LP; Mu, ZH; Lin, XJ; Geng, JL; Xiao, TQ; Zhang, ZJ; Wang, YT; Guan, YJ; Yang, GY
2017
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
卷号9期号:-页码:-
文章类型期刊论文
摘要Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dynamic changes of vascular structure in hypertensive rats using novel synchrotron radiation angiography. Twenty-four spontaneously hypertensive rats (SHR) and 24 Sprague-Dawley (SD) rats underwent synchrotron radiation (SR) angiography. Each group had 8 animals. We studied the cerebral vascular changes in SHR over a time period of 3-12-month and performed quantitative analysis. No vascular morphology differences between SHR and SD rats were observed in the early stage of hypertension. The number of twisted blood vessels in the front brain significantly increased at the 9-and 12-month observation time-points in the SHR compared to the SD rats (p < 0.01). The vessel density of the cortex and the striatum in SHR was consistently higher than that in SD rats at time points of 3-, 9-, and 12-month (p < 0.001). Vascular elasticity decreased both in SHR and SD rats with aging. There were statistically significant differences in the relative vascular elasticity of extracranial/intracranial internal carotid artery, middle cerebral artery, posterior cerebral artery and anterior cerebral artery between SHR and SD rats at 12-month (p < 0.01). We concluded that the dynamic vascular alterations detected by SR angiography provided novel imaging data for the study of hypertension in vivo. The longer the course of hypertension was, the more obvious the vascular differences between the SHR and the SD rats became.
关键词Cerebral-artery Occlusion Blood-brain-barrier Magnetic-resonance Angiography Acute Ischemic-stroke In-vivo Collateral Circulation Mr-angiography Lifetime Risk Model Angiogenesis
DOI10.3389/fnagi.2017.00359
关键词[WOS]CEREBRAL-ARTERY OCCLUSION ; BLOOD-BRAIN-BARRIER ; MAGNETIC-RESONANCE ANGIOGRAPHY ; ACUTE ISCHEMIC-STROKE ; IN-VIVO ; COLLATERAL CIRCULATION ; MR-ANGIOGRAPHY ; LIFETIME RISK ; MODEL ; ANGIOGENESIS
收录类别SCI
语种英语
WOS记录号WOS:000414263300001
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文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28817
专题中科院上海应用物理研究所2011-2018年
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Wang, LP,Mu, ZH,Lin, XJ,et al. Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography[J]. FRONTIERS IN AGING NEUROSCIENCE,2017,9(-):-.
APA Wang, LP.,Mu, ZH.,Lin, XJ.,Geng, JL.,Xiao, TQ.,...&Yang, GY.(2017).Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.FRONTIERS IN AGING NEUROSCIENCE,9(-),-.
MLA Wang, LP,et al."Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography".FRONTIERS IN AGING NEUROSCIENCE 9.-(2017):-.
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