Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems
Wang, T; Wang, L; Li, XM; Hu, XJ; Han, YP; Luo, Y; Wan, ZJ; Li, Q; Aldalbahi, A; Wang, LH; Song, SP; Fang, CH; Zhao, Y; Wang, ML; Chen, N
2017
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:22页码:18619-18625
文章类型期刊论文
摘要Nanopartides (NPs) have ahowia great promise as intracellular imaging probes or nanocarriers and are increasingly being used in biomedical applications. A detailed understanding of how NPs get "in and our of cells is important for developing new nanomkterials with improved selectivity and less cytotoxicify. Both cellular and chemical characteristics have been proven to regulate the cellular uptake of NPs. However, the exocytosis Ness and its regulation are less explored. Herein, we investigated the size-regulated endocytosis and exocytosis of carboxylated polystyrene (PS). NPs, PS NPs with a smaller site were endocytosed mainly through the clathrin-dependent pathlway, whereas PS NPs with a larger size preferred caveolae-mediated endocytosis, Furthermore, our results revealed exocytosis of larger PS NPs and tracked the dynamic process at the single-particle level. These results a indicate that particle size is a key factor for the regulation intracellular trafficking of NPs and provide new insight into the :development of more effective cellular nanocarriers.
关键词Graphene Oxide Nanosheets Engineered Nanoparticles Cellular Uptake Conjugated Polymer Endothelial-cells Endocytosis Mechanisms Entry Cytotoxicity Exocytosis
DOI10.1021/acsami.7b05383
关键词[WOS]GRAPHENE OXIDE NANOSHEETS ; ENGINEERED NANOPARTICLES ; CELLULAR UPTAKE ; CONJUGATED POLYMER ; ENDOTHELIAL-CELLS ; ENDOCYTOSIS ; MECHANISMS ; ENTRY ; CYTOTOXICITY ; EXOCYTOSIS
收录类别SCI
语种英语
WOS记录号WOS:000403136400026
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28820
专题中科院上海应用物理研究所2011-2018年
推荐引用方式
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Wang, T,Wang, L,Li, XM,et al. Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18619-18625.
APA Wang, T.,Wang, L.,Li, XM.,Hu, XJ.,Han, YP.,...&Chen, N.(2017).Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems.ACS APPLIED MATERIALS & INTERFACES,9(22),18619-18625.
MLA Wang, T,et al."Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18619-18625.
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