CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems
Wang, T; Wang, L; Li, XM; Hu, XJ; Han, YP; Luo, Y; Wan, ZJ; Li, Q; Aldalbahi, A; Wang, LH; Song, SP; Fang, CH; Zhao, Y; Wang, ML; Chen, N
2017
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:22Pages:18619-18625
Subtype期刊论文
AbstractNanopartides (NPs) have ahowia great promise as intracellular imaging probes or nanocarriers and are increasingly being used in biomedical applications. A detailed understanding of how NPs get "in and our of cells is important for developing new nanomkterials with improved selectivity and less cytotoxicify. Both cellular and chemical characteristics have been proven to regulate the cellular uptake of NPs. However, the exocytosis Ness and its regulation are less explored. Herein, we investigated the size-regulated endocytosis and exocytosis of carboxylated polystyrene (PS). NPs, PS NPs with a smaller site were endocytosed mainly through the clathrin-dependent pathlway, whereas PS NPs with a larger size preferred caveolae-mediated endocytosis, Furthermore, our results revealed exocytosis of larger PS NPs and tracked the dynamic process at the single-particle level. These results a indicate that particle size is a key factor for the regulation intracellular trafficking of NPs and provide new insight into the :development of more effective cellular nanocarriers.
KeywordGraphene Oxide Nanosheets Engineered Nanoparticles Cellular Uptake Conjugated Polymer Endothelial-cells Endocytosis Mechanisms Entry Cytotoxicity Exocytosis
DOI10.1021/acsami.7b05383
WOS KeywordGRAPHENE OXIDE NANOSHEETS ; ENGINEERED NANOPARTICLES ; CELLULAR UPTAKE ; CONJUGATED POLYMER ; ENDOTHELIAL-CELLS ; ENDOCYTOSIS ; MECHANISMS ; ENTRY ; CYTOTOXICITY ; EXOCYTOSIS
Indexed BySCI
Language英语
WOS IDWOS:000403136400026
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28820
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Wang, T,Wang, L,Li, XM,et al. Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18619-18625.
APA Wang, T.,Wang, L.,Li, XM.,Hu, XJ.,Han, YP.,...&Chen, N.(2017).Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems.ACS APPLIED MATERIALS & INTERFACES,9(22),18619-18625.
MLA Wang, T,et al."Size-Dependent Regulation of Intracellular Trafficking of Polystyrene Nanoparticle-Based Drug-Delivery Systems".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18619-18625.
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