Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo
Yao, CJ; Tu, YS; Ding, L; Li, CC; Wang, J; Fang, HP; Huang, YN; Zhang, KK; Lu, Q; Wu, MH; Wang, YL
2017
发表期刊BIOCONJUGATE CHEMISTRY
ISSN1043-1802
卷号28期号:10页码:2608-2619
文章类型期刊论文
摘要Specific targeting of tumor tissues is essential for tumor imaging and therapeutics but remains challenging. Here, we report an unprecedented method using synthetic sulfonic-graphene quantum dots (sulfonic-GQDs) to exactly target the cancer cell nuclei in vivo without any bio- ligand modification, with no intervention in cells of normal tissues. The key factor for such selectivity is the high interstitial fluid pressure (IFP) in tumor tissues, which allows the penetration of sulfonic-GQDs into the plasma membrane of tumor cells. In vitro, the sulfonic-GQDs are repelled out of the cell membrane because of the repulsive force between negatively charged sulfonic-GQDs and the cell membranes which contributes to the low distribution in normal tissues in vivo. However, the plasma membrane-crossing process can be activated by incubating cells in ultrathin film culture medium because of the attachment of sulfonic-GQDs on cell memebranes. Molecular dynamics simulations demonstrated that, once transported across the plasma membrane, the negatively charged functional groups of these GQDs will leave the membrane with a self-cleaning function retaining a small enough size to achieve penetration through the nuclear membrane into the nucleus. Our study showed that IFP is a previously unrecognized mechanism for specific targeting of tumor cell nuclei and suggested that sulfonic-GQDs may be developed into novel tools for tumor-specific imaging and therapeutics.
关键词Interstitial Fluid Pressure Cancer-therapy Drug-delivery Gene Delivery Nanoparticles Microenvironment Surface Capabilities Liposomes Membranes
DOI10.1021/acs.bioconjchem.7b00466
关键词[WOS]INTERSTITIAL FLUID PRESSURE ; CANCER-THERAPY ; DRUG-DELIVERY ; GENE DELIVERY ; NANOPARTICLES ; MICROENVIRONMENT ; SURFACE ; CAPABILITIES ; LIPOSOMES ; MEMBRANES
收录类别SCI
语种英语
WOS记录号WOS:000413503400014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28883
专题中科院上海应用物理研究所2011-2018年
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Yao, CJ,Tu, YS,Ding, L,et al. Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo[J]. BIOCONJUGATE CHEMISTRY,2017,28(10):2608-2619.
APA Yao, CJ.,Tu, YS.,Ding, L.,Li, CC.,Wang, J.,...&Wang, YL.(2017).Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo.BIOCONJUGATE CHEMISTRY,28(10),2608-2619.
MLA Yao, CJ,et al."Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo".BIOCONJUGATE CHEMISTRY 28.10(2017):2608-2619.
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