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| Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo | |
| Yao, CJ; Tu, YS; Ding, L; Li, CC; Wang, J; Fang, HP; Huang, YN; Zhang, KK; Lu, Q; Wu, MH; Wang, YL | |
| 2017 | |
| Source Publication | BIOCONJUGATE CHEMISTRY
 |
| ISSN | 1043-1802 |
| Volume | 28Issue:10Pages:2608-2619 |
| Subtype | 期刊论文 |
| Abstract | Specific targeting of tumor tissues is essential for tumor imaging and therapeutics but remains challenging. Here, we report an unprecedented method using synthetic sulfonic-graphene quantum dots (sulfonic-GQDs) to exactly target the cancer cell nuclei in vivo without any bio- ligand modification, with no intervention in cells of normal tissues. The key factor for such selectivity is the high interstitial fluid pressure (IFP) in tumor tissues, which allows the penetration of sulfonic-GQDs into the plasma membrane of tumor cells. In vitro, the sulfonic-GQDs are repelled out of the cell membrane because of the repulsive force between negatively charged sulfonic-GQDs and the cell membranes which contributes to the low distribution in normal tissues in vivo. However, the plasma membrane-crossing process can be activated by incubating cells in ultrathin film culture medium because of the attachment of sulfonic-GQDs on cell memebranes. Molecular dynamics simulations demonstrated that, once transported across the plasma membrane, the negatively charged functional groups of these GQDs will leave the membrane with a self-cleaning function retaining a small enough size to achieve penetration through the nuclear membrane into the nucleus. Our study showed that IFP is a previously unrecognized mechanism for specific targeting of tumor cell nuclei and suggested that sulfonic-GQDs may be developed into novel tools for tumor-specific imaging and therapeutics. |
| Keyword | Interstitial Fluid Pressure Cancer-therapy Drug-delivery Gene Delivery Nanoparticles Microenvironment Surface Capabilities Liposomes Membranes |
| DOI | 10.1021/acs.bioconjchem.7b00466 |
| Indexed By | SCI |
| WOS Keyword | INTERSTITIAL FLUID PRESSURE ; CANCER-THERAPY ; DRUG-DELIVERY ; GENE DELIVERY ; NANOPARTICLES ; MICROENVIRONMENT ; SURFACE ; CAPABILITIES ; LIPOSOMES ; MEMBRANES |
| Language | 英语 |
| WOS ID | WOS:000413503400014 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28883 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | Yao, CJ,Tu, YS,Ding, L,et al. Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo[J]. BIOCONJUGATE CHEMISTRY,2017,28(10):2608-2619. |
| APA | Yao, CJ.,Tu, YS.,Ding, L.,Li, CC.,Wang, J.,...&Wang, YL.(2017).Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo.BIOCONJUGATE CHEMISTRY,28(10),2608-2619. |
| MLA | Yao, CJ,et al."Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo".BIOCONJUGATE CHEMISTRY 28.10(2017):2608-2619. |
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| Tumor Cell-Specific （2068KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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