CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo
Yao, CJ; Tu, YS; Ding, L; Li, CC; Wang, J; Fang, HP; Huang, YN; Zhang, KK; Lu, Q; Wu, MH; Wang, YL
2017
Source PublicationBIOCONJUGATE CHEMISTRY
ISSN1043-1802
Volume28Issue:10Pages:2608-2619
Subtype期刊论文
AbstractSpecific targeting of tumor tissues is essential for tumor imaging and therapeutics but remains challenging. Here, we report an unprecedented method using synthetic sulfonic-graphene quantum dots (sulfonic-GQDs) to exactly target the cancer cell nuclei in vivo without any bio- ligand modification, with no intervention in cells of normal tissues. The key factor for such selectivity is the high interstitial fluid pressure (IFP) in tumor tissues, which allows the penetration of sulfonic-GQDs into the plasma membrane of tumor cells. In vitro, the sulfonic-GQDs are repelled out of the cell membrane because of the repulsive force between negatively charged sulfonic-GQDs and the cell membranes which contributes to the low distribution in normal tissues in vivo. However, the plasma membrane-crossing process can be activated by incubating cells in ultrathin film culture medium because of the attachment of sulfonic-GQDs on cell memebranes. Molecular dynamics simulations demonstrated that, once transported across the plasma membrane, the negatively charged functional groups of these GQDs will leave the membrane with a self-cleaning function retaining a small enough size to achieve penetration through the nuclear membrane into the nucleus. Our study showed that IFP is a previously unrecognized mechanism for specific targeting of tumor cell nuclei and suggested that sulfonic-GQDs may be developed into novel tools for tumor-specific imaging and therapeutics.
KeywordInterstitial Fluid Pressure Cancer-therapy Drug-delivery Gene Delivery Nanoparticles Microenvironment Surface Capabilities Liposomes Membranes
DOI10.1021/acs.bioconjchem.7b00466
WOS KeywordINTERSTITIAL FLUID PRESSURE ; CANCER-THERAPY ; DRUG-DELIVERY ; GENE DELIVERY ; NANOPARTICLES ; MICROENVIRONMENT ; SURFACE ; CAPABILITIES ; LIPOSOMES ; MEMBRANES
Indexed BySCI
Language英语
WOS IDWOS:000413503400014
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28883
Collection中科院上海应用物理研究所2011-2018年
Recommended Citation
GB/T 7714
Yao, CJ,Tu, YS,Ding, L,et al. Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo[J]. BIOCONJUGATE CHEMISTRY,2017,28(10):2608-2619.
APA Yao, CJ.,Tu, YS.,Ding, L.,Li, CC.,Wang, J.,...&Wang, YL.(2017).Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo.BIOCONJUGATE CHEMISTRY,28(10),2608-2619.
MLA Yao, CJ,et al."Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo".BIOCONJUGATE CHEMISTRY 28.10(2017):2608-2619.
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