Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo

doi:10.1021/acs.bioconjchem.7b00466

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo
	Yao, CJ; Tu, YS; Ding, L; Li, CC; Wang, J; Fang, HP; Huang, YN; Zhang, KK; Lu, Q; Wu, MH; Wang, YL
	2017
发表期刊	BIOCONJUGATE CHEMISTRY
ISSN	1043-1802
卷号	28 期号:10 页码:2608-2619
文章类型	期刊论文
摘要	Specific targeting of tumor tissues is essential for tumor imaging and therapeutics but remains challenging. Here, we report an unprecedented method using synthetic sulfonic-graphene quantum dots (sulfonic-GQDs) to exactly target the cancer cell nuclei in vivo without any bio- ligand modification, with no intervention in cells of normal tissues. The key factor for such selectivity is the high interstitial fluid pressure (IFP) in tumor tissues, which allows the penetration of sulfonic-GQDs into the plasma membrane of tumor cells. In vitro, the sulfonic-GQDs are repelled out of the cell membrane because of the repulsive force between negatively charged sulfonic-GQDs and the cell membranes which contributes to the low distribution in normal tissues in vivo. However, the plasma membrane-crossing process can be activated by incubating cells in ultrathin film culture medium because of the attachment of sulfonic-GQDs on cell memebranes. Molecular dynamics simulations demonstrated that, once transported across the plasma membrane, the negatively charged functional groups of these GQDs will leave the membrane with a self-cleaning function retaining a small enough size to achieve penetration through the nuclear membrane into the nucleus. Our study showed that IFP is a previously unrecognized mechanism for specific targeting of tumor cell nuclei and suggested that sulfonic-GQDs may be developed into novel tools for tumor-specific imaging and therapeutics.
关键词	Interstitial Fluid Pressure Cancer-therapy Drug-delivery Gene Delivery Nanoparticles Microenvironment Surface Capabilities Liposomes Membranes
DOI	10.1021/acs.bioconjchem.7b00466
关键词[WOS]	INTERSTITIAL FLUID PRESSURE ; CANCER-THERAPY ; DRUG-DELIVERY ; GENE DELIVERY ; NANOPARTICLES ; MICROENVIRONMENT ; SURFACE ; CAPABILITIES ; LIPOSOMES ; MEMBRANES
收录类别	SCI
语种	英语
WOS记录号	WOS:000413503400014
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28883
专题	中科院上海应用物理研究所2011-2018年
推荐引用方式 GB/T 7714	Yao, CJ,Tu, YS,Ding, L,et al. Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo[J]. BIOCONJUGATE CHEMISTRY,2017,28(10):2608-2619.
APA	Yao, CJ.,Tu, YS.,Ding, L.,Li, CC.,Wang, J.,...&Wang, YL.(2017).Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo.BIOCONJUGATE CHEMISTRY,28(10),2608-2619.
MLA	Yao, CJ,et al."Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots in Vivo".BIOCONJUGATE CHEMISTRY 28.10(2017):2608-2619.

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