CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes
Liu, P; Zhao, Y; Liu, XG; Sun, JX; Xu, DD; Li, Y; Li, Q; Wang, LH; Yang, SC; Fan, CH; Lin, JP
2018
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:19Pages:5418-5422
Subtype期刊论文
AbstractReconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of such channels remains challenging owing to the difficulty in probing subtle gating-associated structural changes. Herein, we show that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when its charge is neutralized by Mg2+; whereas Na+ switches it to the expanded state, as revealed by MD simulations, small-angle X-ray scattering (SAXS), and FRET characterization. Furthermore, partial neutralization of the DNA backbone charges by chemical modification renders 6HB compact and insensitive to ions, suggesting an interplay between electrostatic and hydrophobic forces in the channels. This system provides a platform for understanding the structure-function relationship of biological channels and designing rules for the shape control of DNA nanostructures in biomedical applications.
KeywordX-ray-scattering Origami Nanostructures Molecular-dynamics Crystal-structure Channel Membrane Transport Elasticity Mechanisms
DOI10.1002/anie.201801498
Indexed BySCI
Language英语
WOS IDWOS:000431035500041
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28939
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Liu, P
2.Zhao, Y
3.Liu, XG
4.Sun, JX
5.Xu, DD
6.Li, Y
7.Li, Q
8.Wang, LH
9.Yang, SC
10.Fan, CH
11.Lin, JP
Recommended Citation
GB/T 7714
Liu, P,Zhao, Y,Liu, XG,et al. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(19):5418-5422.
APA Liu, P.,Zhao, Y.,Liu, XG.,Sun, JX.,Xu, DD.,...&Lin, JP.(2018).Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(19),5418-5422.
MLA Liu, P,et al."Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.19(2018):5418-5422.
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