Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes
Liu, P; Zhao, Y; Liu, XG; Sun, JX; Xu, DD; Li, Y; Li, Q; Wang, LH; Yang, SC; Fan, CH; Lin, JP
2018
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号57期号:19页码:5418-5422
文章类型期刊论文
摘要Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of such channels remains challenging owing to the difficulty in probing subtle gating-associated structural changes. Herein, we show that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when its charge is neutralized by Mg2+; whereas Na+ switches it to the expanded state, as revealed by MD simulations, small-angle X-ray scattering (SAXS), and FRET characterization. Furthermore, partial neutralization of the DNA backbone charges by chemical modification renders 6HB compact and insensitive to ions, suggesting an interplay between electrostatic and hydrophobic forces in the channels. This system provides a platform for understanding the structure-function relationship of biological channels and designing rules for the shape control of DNA nanostructures in biomedical applications.
关键词X-ray-scattering Origami Nanostructures Molecular-dynamics Crystal-structure Channel Membrane Transport Elasticity Mechanisms
DOI10.1002/anie.201801498
收录类别SCI
语种英语
WOS记录号WOS:000431035500041
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28939
专题中科院上海应用物理研究所2011-2018年
作者单位1.Liu, P
2.Zhao, Y
3.Liu, XG
4.Sun, JX
5.Xu, DD
6.Li, Y
7.Li, Q
8.Wang, LH
9.Yang, SC
10.Fan, CH
11.Lin, JP
推荐引用方式
GB/T 7714
Liu, P,Zhao, Y,Liu, XG,et al. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(19):5418-5422.
APA Liu, P.,Zhao, Y.,Liu, XG.,Sun, JX.,Xu, DD.,...&Lin, JP.(2018).Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(19),5418-5422.
MLA Liu, P,et al."Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.19(2018):5418-5422.
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