CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro
Qian, TT; Liu, YC; Dong, Y; Zhang, L; Dong, YN; Sun, YH; Sun, DM
2018
Source PublicationMOLECULAR MEDICINE REPORTS
ISSN1791-2997
Volume17Issue:3Pages:3633-3639
Subtype期刊论文
AbstractThe chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA-MB-231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771-treated MDA-MB-231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti-metastatic therapy.
KeywordHepatocellular-carcinoma Cells Chemokine Receptor Cxcr7 Mesenchymal Stem-cells Prostate-cancer Growth Expression Lung Prognosis Migration Proliferation
DOI10.3892/mmr.2017.8286
Indexed BySCI
Language英语
WOS IDWOS:000424400000025
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/28955
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Qian, TT
2.Liu, YC
3.Dong, Y
4.Zhang, L
5.Dong, YN
6.Sun, YH
7.Sun, DM
Recommended Citation
GB/T 7714
Qian, TT,Liu, YC,Dong, Y,et al. CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro[J]. MOLECULAR MEDICINE REPORTS,2018,17(3):3633-3639.
APA Qian, TT.,Liu, YC.,Dong, Y.,Zhang, L.,Dong, YN.,...&Sun, DM.(2018).CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro.MOLECULAR MEDICINE REPORTS,17(3),3633-3639.
MLA Qian, TT,et al."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro".MOLECULAR MEDICINE REPORTS 17.3(2018):3633-3639.
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