CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro
Qian, TT; Liu, YC; Dong, Y; Zhang, L; Dong, YN; Sun, YH; Sun, DM
2018
发表期刊MOLECULAR MEDICINE REPORTS
ISSN1791-2997
卷号17期号:3页码:3633-3639
文章类型期刊论文
摘要The chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA-MB-231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771-treated MDA-MB-231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti-metastatic therapy.
关键词Hepatocellular-carcinoma Cells Chemokine Receptor Cxcr7 Mesenchymal Stem-cells Prostate-cancer Growth Expression Lung Prognosis Migration Proliferation
DOI10.3892/mmr.2017.8286
收录类别SCI
语种英语
WOS记录号WOS:000424400000025
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28955
专题中科院上海应用物理研究所2011-2018年
作者单位1.Qian, TT
2.Liu, YC
3.Dong, Y
4.Zhang, L
5.Dong, YN
6.Sun, YH
7.Sun, DM
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Qian, TT,Liu, YC,Dong, Y,et al. CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro[J]. MOLECULAR MEDICINE REPORTS,2018,17(3):3633-3639.
APA Qian, TT.,Liu, YC.,Dong, Y.,Zhang, L.,Dong, YN.,...&Sun, DM.(2018).CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro.MOLECULAR MEDICINE REPORTS,17(3),3633-3639.
MLA Qian, TT,et al."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro".MOLECULAR MEDICINE REPORTS 17.3(2018):3633-3639.
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