CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro

doi:10.3892/mmr.2017.8286

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro
	Qian, TT ; Liu, YC ; Dong, Y ; Zhang, L ; Dong, YN ; Sun, YH ; Sun, DM
	2018
发表期刊	MOLECULAR MEDICINE REPORTS
ISSN	1791-2997
卷号	17 期号:3 页码:3633-3639
文章类型	期刊论文
摘要	The chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA-MB-231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771-treated MDA-MB-231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti-metastatic therapy.
关键词	Hepatocellular-carcinoma Cells Chemokine Receptor Cxcr7 Mesenchymal Stem-cells Prostate-cancer Growth Expression Lung Prognosis Migration Proliferation
DOI	10.3892/mmr.2017.8286
收录类别	SCI
语种	英语
WOS记录号	WOS:000424400000025
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/28955
专题	中科院上海应用物理研究所2011-2018年
作者单位	1.Qian, TT 2.Liu, YC 3.Dong, Y 4.Zhang, L 5.Dong, YN 6.Sun, YH 7.Sun, DM
推荐引用方式 GB/T 7714	Qian, TT,Liu, YC,Dong, Y,et al. CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro[J]. MOLECULAR MEDICINE REPORTS,2018,17(3):3633-3639.
APA	Qian, TT.,Liu, YC.,Dong, Y.,Zhang, L.,Dong, YN.,...&Sun, DM.(2018).CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro.MOLECULAR MEDICINE REPORTS,17(3),3633-3639.
MLA	Qian, TT,et al."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro".MOLECULAR MEDICINE REPORTS 17.3(2018):3633-3639.

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