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| CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro | |
| Qian, TT; Liu, YC; Dong, Y; Zhang, L; Dong, YN; Sun, YH; Sun, DM | |
| 2018 | |
| Source Publication | MOLECULAR MEDICINE REPORTS
 |
| ISSN | 1791-2997 |
| Volume | 17Issue:3Pages:3633-3639 |
| Subtype | 期刊论文 |
| Abstract | The chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA-MB-231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771-treated MDA-MB-231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti-metastatic therapy. |
| Keyword | Hepatocellular-carcinoma Cells Chemokine Receptor Cxcr7 Mesenchymal Stem-cells Prostate-cancer Growth Expression Lung Prognosis Migration Proliferation |
| DOI | 10.3892/mmr.2017.8286 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000424400000025 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/28955 |
| Collection | 中科院上海应用物理研究所2011-2018年 |
| Affiliation | 1.Qian, TT 2.Liu, YC 3.Dong, Y 4.Zhang, L 5.Dong, YN 6.Sun, YH 7.Sun, DM |
| Recommended Citation GB/T 7714 | Qian, TT,Liu, YC,Dong, Y,et al. CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro[J]. MOLECULAR MEDICINE REPORTS,2018,17(3):3633-3639. |
| APA | Qian, TT.,Liu, YC.,Dong, Y.,Zhang, L.,Dong, YN.,...&Sun, DM.(2018).CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro.MOLECULAR MEDICINE REPORTS,17(3),3633-3639. |
| MLA | Qian, TT,et al."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro".MOLECULAR MEDICINE REPORTS 17.3(2018):3633-3639. |
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| CXCR7 regulates brea（1426KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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