Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism
Wang, L; Wang, ZJ; Li, XM; Zhang, Y; Yin, M; Li, J; Song, HY; Shi, JY; Ling, DS; Wang, LH; Chen, N; Fan, CH
2018
发表期刊NANO RESEARCH
ISSN1998-0124
卷号11期号:5页码:2746-2755
文章类型期刊论文
摘要Magnetite nanoparticles (Fe3O4 NPs) are a well proven biocompatible nanomaterial, which hold great promise in various biomedical applications. Interestingly, unlike conventional biocompatible materials (e.g., polyethylene glycol (PEG)) that are chemically and biologically inert in nature, Fe3O4 NPs are known to be catalytically active and exhibit prominent physiological effects. Herein, we report an "active", dynamic equilibrium mechanism for maintaining the cellular amenity of Fe3O4 NPs. We examined the effects of two types of iron oxide (magnetite and hematite) NPs in rat pheochromocytoma (PC12) cells and found that both induced stress responses. However, only Fe2O3 NPs caused significant programmed cell death; whereas Fe3O4 NPs are amenable to cells. We found that intrinsic catalase-like activity of Fe3O4 NPs antagonized the accumulation of toxic reactive oxygen species (ROS) induced by themselves, and thereby modulated the extent of cellular oxidative stress, autophagic activity, and programmed cell death. In line with this observation, we effectively reversed severe autophagy and cell death caused by Fe2O3 NPs via co-treatment with natural catalase. This study not only deciphers the distinct intrinsic antagonism of Fe3O4 NPs, but opens new routes to designing biocompatible theranostic nanoparticles with novel mechanisms.
关键词Mesenchymal Stem-cells Magnetic Nanoparticles Induced Autophagy Oxidative Stress Cancer-cells In-vitro Cytotoxicity Apoptosis Graphene Therapy
DOI10.1007/s12274-017-1905-8
收录类别SCI
语种英语
WOS记录号WOS:000431999700039
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/28957
专题中科院上海应用物理研究所2011-2018年
作者单位1.Wang, L
2.Wang, ZJ
3.Li, XM
4.Zhang, Y
5.Yin, M
6.Li, J
7.Song, HY
8.Shi, JY
9.Ling, DS
10.Wang, LH
11.Chen, N
12.Fan, CH
推荐引用方式
GB/T 7714
Wang, L,Wang, ZJ,Li, XM,et al. Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism[J]. NANO RESEARCH,2018,11(5):2746-2755.
APA Wang, L.,Wang, ZJ.,Li, XM.,Zhang, Y.,Yin, M.,...&Fan, CH.(2018).Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism.NANO RESEARCH,11(5),2746-2755.
MLA Wang, L,et al."Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism".NANO RESEARCH 11.5(2018):2746-2755.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Deciphering active b(1913KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, L]的文章
[Wang, ZJ]的文章
[Li, XM]的文章
百度学术
百度学术中相似的文章
[Wang, L]的文章
[Wang, ZJ]的文章
[Li, XM]的文章
必应学术
必应学术中相似的文章
[Wang, L]的文章
[Wang, ZJ]的文章
[Li, XM]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。