Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation
Chen, B; Sun, JF; Fan, FG; Zhang, XZ; Qin, ZG; Wang, P; Li, Y; Zhang, XQ; Liu, F; Liu, YL; Ji, M; Gu, N
2018
发表期刊NANOSCALE
ISSN2040-3364
卷号10期号:16页码:7369-7376
文章类型期刊论文
摘要Ferumoxytol, which is originally intended for MRI and anemia treatment, is currently the only inorganic nanodrug approved by FDA for clinical application in vivo. Common ferumoxytol seems incapable of meeting the requirements for diverse applications. Thus, the development of a novel strategy based on co-precipitation to produce ferumoxytol with high quality is an imminent task. Herein, we proposed a physically assisted strategy, namely hydrocooling and magnetically internal heating co-precipitation, to optimize the properties of ferumoxytol and thus significantly enhance its magnetic performance. Magnetization of the newly developed ferumoxytol can reach 104-105 emu g(-1) Fe, which is the highest value among the reported results. It has been found that the crystalline structures of the newly developed ferumoxytol have been greatly improved on the basis of pharmaceutical quality criteria.
关键词Iron-oxide Nanoparticles Electron-paramagnetic-resonance Mri Contrast Agents Field Control Nanomaterials Nanostructures Temperature Particles Design
DOI10.1039/c8nr00736e
收录类别SCI
语种英语
WOS记录号WOS:000431030000006
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29020
专题中科院上海应用物理研究所2011-2018年
作者单位1.Chen, B
2.Sun, JF
3.Fan, FG
4.Zhang, XZ
5.Qin, ZG
6.Wang, P
7.Li, Y
8.Zhang, XQ
9.Liu, F
10.Liu, YL
11.Ji, M
12.Gu, N
推荐引用方式
GB/T 7714
Chen, B,Sun, JF,Fan, FG,et al. Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation[J]. NANOSCALE,2018,10(16):7369-7376.
APA Chen, B.,Sun, JF.,Fan, FG.,Zhang, XZ.,Qin, ZG.,...&Gu, N.(2018).Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation.NANOSCALE,10(16),7369-7376.
MLA Chen, B,et al."Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation".NANOSCALE 10.16(2018):7369-7376.
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