CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation
Chen, B; Sun, JF; Fan, FG; Zhang, XZ; Qin, ZG; Wang, P; Li, Y; Zhang, XQ; Liu, F; Liu, YL; Ji, M; Gu, N
2018
Source PublicationNANOSCALE
ISSN2040-3364
Volume10Issue:16Pages:7369-7376
Subtype期刊论文
AbstractFerumoxytol, which is originally intended for MRI and anemia treatment, is currently the only inorganic nanodrug approved by FDA for clinical application in vivo. Common ferumoxytol seems incapable of meeting the requirements for diverse applications. Thus, the development of a novel strategy based on co-precipitation to produce ferumoxytol with high quality is an imminent task. Herein, we proposed a physically assisted strategy, namely hydrocooling and magnetically internal heating co-precipitation, to optimize the properties of ferumoxytol and thus significantly enhance its magnetic performance. Magnetization of the newly developed ferumoxytol can reach 104-105 emu g(-1) Fe, which is the highest value among the reported results. It has been found that the crystalline structures of the newly developed ferumoxytol have been greatly improved on the basis of pharmaceutical quality criteria.
KeywordIron-oxide Nanoparticles Electron-paramagnetic-resonance Mri Contrast Agents Field Control Nanomaterials Nanostructures Temperature Particles Design
DOI10.1039/c8nr00736e
Indexed BySCI
Language英语
WOS IDWOS:000431030000006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29020
Collection中科院上海应用物理研究所2011-2019年
Affiliation1.Chen, B
2.Sun, JF
3.Fan, FG
4.Zhang, XZ
5.Qin, ZG
6.Wang, P
7.Li, Y
8.Zhang, XQ
9.Liu, F
10.Liu, YL
11.Ji, M
12.Gu, N
Recommended Citation
GB/T 7714
Chen, B,Sun, JF,Fan, FG,et al. Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation[J]. NANOSCALE,2018,10(16):7369-7376.
APA Chen, B.,Sun, JF.,Fan, FG.,Zhang, XZ.,Qin, ZG.,...&Gu, N.(2018).Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation.NANOSCALE,10(16),7369-7376.
MLA Chen, B,et al."Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation".NANOSCALE 10.16(2018):7369-7376.
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