Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects
Zhao, RT; Kong, W; Sun, MX; Yang, Y; Liu, WY; Lv, M; Song, SP; Wang, LH; Song, HB; Hao, RZ
2018
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号10期号:21页码:17617-17629
文章类型期刊论文
摘要Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO-Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. This study aimed to synthesize a polyethyleneimine (PEI)-modified and AgNP-decorated GO nanocomposite (GO-PEI-Ag) through a facile approach through microwave irradiation without any extra reductants and surfactants; its antimicrobial activity was investigated on Gram-negative/-positive bacteria (including drug-resistant bacteria) and fungi. Compared with GO-Ag, GO-PEI-Ag acquired excellent stability in physiological solutions and electropositivity, showing substantially higher antimicrobial efficacy. Moreover, GO-PEI-Ag exhibited particularly excellent long-term effects, presenting no obvious decline in antimicrobial activity after 1 week storage in physiological saline and repeated use for three times and the lasting inhibition of bacterial growth in nutrient-rich culture medium. In contrast, GO-Ag exhibited a >60% decline in antimicrobial activity after storage. Importantly, GO-PEI-Ag effectively eliminated adhered bacteria, thereby preventing biofilm formation. The primary antimicrobial mechanisms of GO PEI-Ag were evidenced as physical damage to the pathogen structure, causing cytoplasmic leakage. Hence, stable GO-PEI-Ag with robust, long-term antimicrobial activity holds promise in combating public-health threats posed by drug-resistant bacteria and biofilms.
关键词Silver Nanoparticles Antibacterial Activity Infectious-diseases Escherichia-coli Drug-delivery Oxide Nanomaterials Mechanisms Cells Resistance
DOI10.1021/acsami.8b03185
收录类别SCI
语种英语
WOS记录号WOS:000434101200013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29033
专题中科院上海应用物理研究所2011-2018年
作者单位1.Zhao, RT
2.Kong, W
3.Sun, MX
4.Yang, Y
5.Liu, WY
6.Lv, M
7.Song, SP
8.Wang, LH
9.Song, HB
10.Hao, RZ
推荐引用方式
GB/T 7714
Zhao, RT,Kong, W,Sun, MX,et al. Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(21):17617-17629.
APA Zhao, RT.,Kong, W.,Sun, MX.,Yang, Y.,Liu, WY.,...&Hao, RZ.(2018).Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects.ACS APPLIED MATERIALS & INTERFACES,10(21),17617-17629.
MLA Zhao, RT,et al."Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects".ACS APPLIED MATERIALS & INTERFACES 10.21(2018):17617-17629.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Highly Stable Graphe(7718KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, RT]的文章
[Kong, W]的文章
[Sun, MX]的文章
百度学术
百度学术中相似的文章
[Zhao, RT]的文章
[Kong, W]的文章
[Sun, MX]的文章
必应学术
必应学术中相似的文章
[Zhao, RT]的文章
[Kong, W]的文章
[Sun, MX]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Highly Stable Graphene-Based Nanocomposite (GO-PEI-Ag) with Broad-Spectrum, Long-Term Antimicrobial Activity and Antibiofilm Effects.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。