Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission
Xu, G; Yan, QL; Lv, XG; Zhu, Y; Xin, K; Shi, B; Wang, RC; Chen, J; Gao, W; Shi, P; Fan, CH; Zhao, CC; Tian, H
2018
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号57期号:14页码:3626-3630
文章类型期刊论文
摘要Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300nm. By using this activatable and target specific probe for deep-tissue imaging of H2S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.
关键词In-vivo Fluorescence Hydrogen-sulfide Carbon Nanotubes Biological-systems Ii Fluorescence Probes Cells Mice Dye Nanoparticles
DOI10.1002/anie.201712528
收录类别SCI
语种英语
WOS记录号WOS:000428350100013
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29038
专题中科院上海应用物理研究所2011-2018年
作者单位1.Xu, G
2.Yan, QL
3.Lv, XG
4.Zhu, Y
5.Xin, K
6.Shi, B
7.Wang, RC
8.Chen, J
9.Gao, W
10.Shi, P
11.Fan, CH
12.Zhao, CC
13.Tian, H
推荐引用方式
GB/T 7714
Xu, G,Yan, QL,Lv, XG,et al. Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3626-3630.
APA Xu, G.,Yan, QL.,Lv, XG.,Zhu, Y.,Xin, K.,...&Tian, H.(2018).Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3626-3630.
MLA Xu, G,et al."Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3626-3630.
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