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Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric
Li, R; Cai, XM; Ye, Y; Wu, GZ
2018
Source PublicationJOURNAL OF APPLIED POLYMER SCIENCE
ISSN0021-8995
Volume135Issue:9Pages:-
Subtype期刊论文
AbstractThe sulfonated polypropylene non-woven fabric (PPNWF) was successfully fabricated via gamma-ray simultaneous radiationinduced graft polymerization of acrylic acid (AA)/sodium styrenesulfonate (NaSS) and acrylamide (AAm)/NaSS. The existence of graft chains in both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) was proved by attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Water contact angle measurement illustrated the sulfonated PPNWF owning good hydrophilicity. The in vitro hemocompatibility evaluation showed that both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) inhibited effectively the adhesion of platelets and were significantly compatible with erythrocytes. Moreover, no obvious difference was confirmed in the prevention of platelet adhesion and hemolysis ratio between carboxyl and amide groups. However, as compared with that of PP-g-P(AAm-co-NaSS), PP-g-P(AA-co-NaSS) exhibited outstanding anticoagulant activity via increased activated partial thromboplastin time and thrombin time. This result indicated that the carboxyl group but not amide group featured strong synergistic effect on the anticoagulant activity of sulfonated PPNWF. (C) 2017 Wiley Periodicals, Inc.
KeywordInduced Graft-polymerization Anticoagulant Activity Blood Compatibility Styrene-sulfonate Heparin Chitosan Surface Biocompatibility Antibacterial Particles
DOI10.1002/APP.45915
Indexed BySCI
Language英语
WOS IDWOS:000417600100019
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29048
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Li, R
2.Cai, XM
3.Ye, Y
4.Wu, GZ
Recommended Citation
GB/T 7714
Li, R,Cai, XM,Ye, Y,et al. Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2018,135(9):-.
APA Li, R,Cai, XM,Ye, Y,&Wu, GZ.(2018).Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric.JOURNAL OF APPLIED POLYMER SCIENCE,135(9),-.
MLA Li, R,et al."Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric".JOURNAL OF APPLIED POLYMER SCIENCE 135.9(2018):-.
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