Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric
Li, R; Cai, XM; Ye, Y; Wu, GZ
2018
发表期刊JOURNAL OF APPLIED POLYMER SCIENCE
ISSN0021-8995
卷号135期号:9页码:-
文章类型期刊论文
摘要The sulfonated polypropylene non-woven fabric (PPNWF) was successfully fabricated via gamma-ray simultaneous radiationinduced graft polymerization of acrylic acid (AA)/sodium styrenesulfonate (NaSS) and acrylamide (AAm)/NaSS. The existence of graft chains in both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) was proved by attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Water contact angle measurement illustrated the sulfonated PPNWF owning good hydrophilicity. The in vitro hemocompatibility evaluation showed that both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) inhibited effectively the adhesion of platelets and were significantly compatible with erythrocytes. Moreover, no obvious difference was confirmed in the prevention of platelet adhesion and hemolysis ratio between carboxyl and amide groups. However, as compared with that of PP-g-P(AAm-co-NaSS), PP-g-P(AA-co-NaSS) exhibited outstanding anticoagulant activity via increased activated partial thromboplastin time and thrombin time. This result indicated that the carboxyl group but not amide group featured strong synergistic effect on the anticoagulant activity of sulfonated PPNWF. (C) 2017 Wiley Periodicals, Inc.
关键词Induced Graft-polymerization Anticoagulant Activity Blood Compatibility Styrene-sulfonate Heparin Chitosan Surface Biocompatibility Antibacterial Particles
DOI10.1002/APP.45915
收录类别SCI
语种英语
WOS记录号WOS:000417600100019
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29048
专题中科院上海应用物理研究所2011-2018年
作者单位1.Li, R
2.Cai, XM
3.Ye, Y
4.Wu, GZ
推荐引用方式
GB/T 7714
Li, R,Cai, XM,Ye, Y,et al. Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2018,135(9):-.
APA Li, R,Cai, XM,Ye, Y,&Wu, GZ.(2018).Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric.JOURNAL OF APPLIED POLYMER SCIENCE,135(9),-.
MLA Li, R,et al."Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric".JOURNAL OF APPLIED POLYMER SCIENCE 135.9(2018):-.
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