Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation
He, SF; Fan, WW; Wu, N; Zhu, JJ; Miao, YQ; Miao, XR; Li, FF; Zhang, XX; Gan, Y
2018
发表期刊NANO LETTERS
ISSN1530-6984
卷号18期号:4页码:2411-2419
文章类型期刊论文
摘要RNA interference (RNAi) technology has shown great promise for the treatment of cancer and other genetic disorders. Despite the efforts to increase the target tissue distribution, the safe and effective delivery of siRNA to the diseased cells with sufficient cytosolic transport is another critical factor for successful RNAi clinical application. Here, the constructed lipid-based liquid crystalline nanoparticles, called nano-Transformers, can transform the structure in the intracellular acidic environment and perform high-efficient siRNA delivery for cancer treatment. The developed nano-Transformers have satisfactory siRNA loading efficiency and low cytotoxicity. Different from the traditional cationic nanocarriers, the endosomal membrane fusion induced by the conformational transition of lipids contributes to the easy dissociation of siRNA from nanocarriers and direct release of free siRNA into cytoplasm. We show that transfection with cyclin-dependent kinase 1 (CDK1)-siRNA-loaded nano-Transformers causes up to 95% reduction of relevant mRNA in vitro and greatly inhibits the tumor growth without causing any immunogenic response in vivo. This work highlights that the lipid-based nano-Transformers may become the next generation of siRNA delivery system with higher efficacy and improved safety profiles.
关键词Gene Delivery Drug-delivery Viral Vectors Nonviral Vectors Therapy Therapeutics Nanocarriers Rnai Ph Inhibition
DOI10.1021/acs.nanolett.7b05430
收录类别SCI
语种英语
WOS记录号WOS:000430155900031
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29061
专题中科院上海应用物理研究所2011-2018年
作者单位1.He, SF
2.Fan, WW
3.Wu, N
4.Zhu, JJ
5.Miao, YQ
6.Miao, XR
7.Li, FF
8.Zhang, XX
9.Gan, Y
推荐引用方式
GB/T 7714
He, SF,Fan, WW,Wu, N,et al. Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation[J]. NANO LETTERS,2018,18(4):2411-2419.
APA He, SF.,Fan, WW.,Wu, N.,Zhu, JJ.,Miao, YQ.,...&Gan, Y.(2018).Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation.NANO LETTERS,18(4),2411-2419.
MLA He, SF,et al."Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation".NANO LETTERS 18.4(2018):2411-2419.
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