Logic Catalytic Interconversion of G-Molecular Hydrogel

doi:10.1021/acsami.7b17926

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Logic Catalytic Interconversion of G-Molecular Hydrogel
	Zhong, RB ; Xiao, MS ; Zhu, CF ; Shen, XZ ; Tang, Q ; Zhang, WJ ; Wang, LH ; Song, SP ; Qu, XM ; Pei, H ; Wang, C ; Li, L
	2018
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	10 期号:5 页码:4512-4518
文章类型	期刊论文
摘要	By incorporating hemin into G-quadruplex (G(4)) during cation-templated self-assembly between guanosine and KB(OH)(4), we have constructed an artificial enzyme hydrogel (AEH)-based system for the highly sensitive and selective detection of Pb2+. The sensing strategy is based on a Pb2+-induced decrease in AEH activity. Because of the higher efficiency of Pb2+ for stabilizing G(4) compared with the Pb2+ ions substitute K+ and trigger hemin release from G(4), thus giving rise to a conformational interconversion accompanied by the loss of enzyme activity. The Pb2+-induced catalytic interconversion endows the AEH-based system with high sensitivity and selectivity for detecting Pb2+. As a result, the AEH-based system shows an excellent response for Pb2+ in the range from 1 pM to 50 nM with a limit of detection of similar to 0.32 pM, which is much lower than that of the previously reported G(4)-DNAzyme. We also demonstrate that this AEH-based system exhibits high selectivity toward Pb2+ over other metal ions. Furthermore, two two-input INHIBIT logic gates have been constructed via switching of the catalytic interconversion induced by and Pb2+ or K+ and pH. Given its versatility, this AEH-based system provides a novel platform for sensing and biomolecular computation.
关键词	G-quadruplex Dna Nanostructure Horseradish-peroxidase Fluorescence Detection Sensitive Hydrogels Gold Nanoparticles Drug-delivery Ion Dnazymes Nanogels
DOI	10.1021/acsami.7b17926
收录类别	SCI
语种	英语
WOS记录号	WOS:000424851600017
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/29062
专题	中科院上海应用物理研究所2011-2018年
作者单位	1.Zhong, RB 2.Xiao, MS 3.Zhu, CF 4.Shen, XZ 5.Tang, Q 6.Zhang, WJ 7.Wang, LH 8.Song, SP 9.Qu, XM 10.Pei, H 11.Wang, C 12.Li, L
推荐引用方式 GB/T 7714	Zhong, RB,Xiao, MS,Zhu, CF,et al. Logic Catalytic Interconversion of G-Molecular Hydrogel[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(5):4512-4518.
APA	Zhong, RB.,Xiao, MS.,Zhu, CF.,Shen, XZ.,Tang, Q.,...&Li, L.(2018).Logic Catalytic Interconversion of G-Molecular Hydrogel.ACS APPLIED MATERIALS & INTERFACES,10(5),4512-4518.
MLA	Zhong, RB,et al."Logic Catalytic Interconversion of G-Molecular Hydrogel".ACS APPLIED MATERIALS & INTERFACES 10.5(2018):4512-4518.

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