CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Logic Catalytic Interconversion of G-Molecular Hydrogel
Zhong, RB; Xiao, MS; Zhu, CF; Shen, XZ; Tang, Q; Zhang, WJ; Wang, LH; Song, SP; Qu, XM; Pei, H; Wang, C; Li, L
AbstractBy incorporating hemin into G-quadruplex (G(4)) during cation-templated self-assembly between guanosine and KB(OH)(4), we have constructed an artificial enzyme hydrogel (AEH)-based system for the highly sensitive and selective detection of Pb2+. The sensing strategy is based on a Pb2+-induced decrease in AEH activity. Because of the higher efficiency of Pb2+ for stabilizing G(4) compared with the Pb2+ ions substitute K+ and trigger hemin release from G(4), thus giving rise to a conformational interconversion accompanied by the loss of enzyme activity. The Pb2+-induced catalytic interconversion endows the AEH-based system with high sensitivity and selectivity for detecting Pb2+. As a result, the AEH-based system shows an excellent response for Pb2+ in the range from 1 pM to 50 nM with a limit of detection of similar to 0.32 pM, which is much lower than that of the previously reported G(4)-DNAzyme. We also demonstrate that this AEH-based system exhibits high selectivity toward Pb2+ over other metal ions. Furthermore, two two-input INHIBIT logic gates have been constructed via switching of the catalytic interconversion induced by and Pb2+ or K+ and pH. Given its versatility, this AEH-based system provides a novel platform for sensing and biomolecular computation.
KeywordG-quadruplex Dna Nanostructure Horseradish-peroxidase Fluorescence Detection Sensitive Hydrogels Gold Nanoparticles Drug-delivery Ion Dnazymes Nanogels
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WOS IDWOS:000424851600017
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Document Type期刊论文
Affiliation1.Zhong, RB
2.Xiao, MS
3.Zhu, CF
4.Shen, XZ
5.Tang, Q
6.Zhang, WJ
7.Wang, LH
8.Song, SP
9.Qu, XM
10.Pei, H
11.Wang, C
12.Li, L
Recommended Citation
GB/T 7714
Zhong, RB,Xiao, MS,Zhu, CF,et al. Logic Catalytic Interconversion of G-Molecular Hydrogel[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(5):4512-4518.
APA Zhong, RB.,Xiao, MS.,Zhu, CF.,Shen, XZ.,Tang, Q.,...&Li, L.(2018).Logic Catalytic Interconversion of G-Molecular Hydrogel.ACS APPLIED MATERIALS & INTERFACES,10(5),4512-4518.
MLA Zhong, RB,et al."Logic Catalytic Interconversion of G-Molecular Hydrogel".ACS APPLIED MATERIALS & INTERFACES 10.5(2018):4512-4518.
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