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| Logic Catalytic Interconversion of G-Molecular Hydrogel | |
| Zhong, RB; Xiao, MS; Zhu, CF; Shen, XZ; Tang, Q; Zhang, WJ; Wang, LH; Song, SP; Qu, XM; Pei, H; Wang, C; Li, L | |
| 2018 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 10Issue:5Pages:4512-4518 |
| Subtype | 期刊论文 |
| Abstract | By incorporating hemin into G-quadruplex (G(4)) during cation-templated self-assembly between guanosine and KB(OH)(4), we have constructed an artificial enzyme hydrogel (AEH)-based system for the highly sensitive and selective detection of Pb2+. The sensing strategy is based on a Pb2+-induced decrease in AEH activity. Because of the higher efficiency of Pb2+ for stabilizing G(4) compared with the Pb2+ ions substitute K+ and trigger hemin release from G(4), thus giving rise to a conformational interconversion accompanied by the loss of enzyme activity. The Pb2+-induced catalytic interconversion endows the AEH-based system with high sensitivity and selectivity for detecting Pb2+. As a result, the AEH-based system shows an excellent response for Pb2+ in the range from 1 pM to 50 nM with a limit of detection of similar to 0.32 pM, which is much lower than that of the previously reported G(4)-DNAzyme. We also demonstrate that this AEH-based system exhibits high selectivity toward Pb2+ over other metal ions. Furthermore, two two-input INHIBIT logic gates have been constructed via switching of the catalytic interconversion induced by and Pb2+ or K+ and pH. Given its versatility, this AEH-based system provides a novel platform for sensing and biomolecular computation. |
| Keyword | G-quadruplex Dna Nanostructure Horseradish-peroxidase Fluorescence Detection Sensitive Hydrogels Gold Nanoparticles Drug-delivery Ion Dnazymes Nanogels |
| DOI | 10.1021/acsami.7b17926 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000424851600017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/29062 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Affiliation | 1.Zhong, RB 2.Xiao, MS 3.Zhu, CF 4.Shen, XZ 5.Tang, Q 6.Zhang, WJ 7.Wang, LH 8.Song, SP 9.Qu, XM 10.Pei, H 11.Wang, C 12.Li, L |
| Recommended Citation GB/T 7714 | Zhong, RB,Xiao, MS,Zhu, CF,et al. Logic Catalytic Interconversion of G-Molecular Hydrogel[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(5):4512-4518. |
| APA | Zhong, RB.,Xiao, MS.,Zhu, CF.,Shen, XZ.,Tang, Q.,...&Li, L.(2018).Logic Catalytic Interconversion of G-Molecular Hydrogel.ACS APPLIED MATERIALS & INTERFACES,10(5),4512-4518. |
| MLA | Zhong, RB,et al."Logic Catalytic Interconversion of G-Molecular Hydrogel".ACS APPLIED MATERIALS & INTERFACES 10.5(2018):4512-4518. |
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| Logic Catalytic Inte（2307KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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