Nanoscale delivery systems for cancer immunotherapy
Wang, ZJ; Liu, WH; Shi, JY; Chen, N; Fan, CH
2018
发表期刊MATERIALS HORIZONS
ISSN2051-6347
卷号5期号:3页码:344-362
文章类型期刊论文
摘要Increased understanding of tumor immunology has prompted rapid development of cancer immunotherapy in the past few years. The recent clinical success of immunotherapeutic approaches, such as immune checkpoint blockade and chimeric antigen receptor T cells, demonstrates their potential as a cancer terminator. Nevertheless, strategies to improve the overall efficiency and to reduce the side effects of immunotherapy are highly demanded. Nano-delivery systems hold great promise in biomedical applications due to their unique physiochemical properties and advantages in efficient tissue-specific delivery, enhanced cellular uptake and responsiveness to physiological and environmental stimuli. Immuno-nanomedicine opens a new field in cancer treatment and has attracted broad interest. In this review, we present recent advances in the field of cancer immunotherapy and focus on the nanocarrier-mediated delivery of immunomodulators as well as manipulation of immune cells. Applications of various types of nanomaterials (inorganic, polymers, liposomes, DNA-based, biomimetic and bio-derived nanoparticles) are summarized. Challenges and opportunities of nanovehicles in cancer immuno-oncology are also discussed.
关键词Car-t-cells Antigen-presenting Cells Tumor-infiltrating Lymphocytes Membrane-coated Nanoparticles Iron-oxide Nanoparticles Enhanced Immune-response Virus-like Particles Drug-delivery Photothermal Therapy In-vivo
DOI10.1039/c7mh00991g
收录类别SCI
语种英语
WOS记录号WOS:000431741300002
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29081
专题中科院上海应用物理研究所2011-2018年
作者单位1.Wang, ZJ
2.Liu, WH
3.Shi, JY
4.Chen, N
5.Fan, CH
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Wang, ZJ,Liu, WH,Shi, JY,et al. Nanoscale delivery systems for cancer immunotherapy[J]. MATERIALS HORIZONS,2018,5(3):344-362.
APA Wang, ZJ,Liu, WH,Shi, JY,Chen, N,&Fan, CH.(2018).Nanoscale delivery systems for cancer immunotherapy.MATERIALS HORIZONS,5(3),344-362.
MLA Wang, ZJ,et al."Nanoscale delivery systems for cancer immunotherapy".MATERIALS HORIZONS 5.3(2018):344-362.
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