CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Nanoscale delivery systems for cancer immunotherapy
Wang, ZJ; Liu, WH; Shi, JY; Chen, N; Fan, CH
AbstractIncreased understanding of tumor immunology has prompted rapid development of cancer immunotherapy in the past few years. The recent clinical success of immunotherapeutic approaches, such as immune checkpoint blockade and chimeric antigen receptor T cells, demonstrates their potential as a cancer terminator. Nevertheless, strategies to improve the overall efficiency and to reduce the side effects of immunotherapy are highly demanded. Nano-delivery systems hold great promise in biomedical applications due to their unique physiochemical properties and advantages in efficient tissue-specific delivery, enhanced cellular uptake and responsiveness to physiological and environmental stimuli. Immuno-nanomedicine opens a new field in cancer treatment and has attracted broad interest. In this review, we present recent advances in the field of cancer immunotherapy and focus on the nanocarrier-mediated delivery of immunomodulators as well as manipulation of immune cells. Applications of various types of nanomaterials (inorganic, polymers, liposomes, DNA-based, biomimetic and bio-derived nanoparticles) are summarized. Challenges and opportunities of nanovehicles in cancer immuno-oncology are also discussed.
KeywordCar-t-cells Antigen-presenting Cells Tumor-infiltrating Lymphocytes Membrane-coated Nanoparticles Iron-oxide Nanoparticles Enhanced Immune-response Virus-like Particles Drug-delivery Photothermal Therapy In-vivo
Indexed BySCI
WOS IDWOS:000431741300002
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Document Type期刊论文
Affiliation1.Wang, ZJ
2.Liu, WH
3.Shi, JY
4.Chen, N
5.Fan, CH
Recommended Citation
GB/T 7714
Wang, ZJ,Liu, WH,Shi, JY,et al. Nanoscale delivery systems for cancer immunotherapy[J]. MATERIALS HORIZONS,2018,5(3):344-362.
APA Wang, ZJ,Liu, WH,Shi, JY,Chen, N,&Fan, CH.(2018).Nanoscale delivery systems for cancer immunotherapy.MATERIALS HORIZONS,5(3),344-362.
MLA Wang, ZJ,et al."Nanoscale delivery systems for cancer immunotherapy".MATERIALS HORIZONS 5.3(2018):344-362.
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