Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome
Liu, XY; Xu, HX; Li, JK; Zhang, D; Ma, XH; Huang, LN; Lu, JH; Wang, XZ
2018
发表期刊FRONTIERS IN PHYSIOLOGY
ISSN1664-042X
卷号9页码:-
文章类型期刊论文
摘要Damage to the endothelial glycocalyx is a critical factor in increased pulmonary vascular permeability, which is the basic pathological feature of acute respiratory distress syndrome (ARDS). Neferine (Nef), a bisbenzylisoquinoline alkaloid isolated from green seed embryos of Nelumbo nucifera Gaertn, has extensive pharmacological activity. In this study, we showed that Nef reduced lung-capillary permeability, down-regulated the production of cytokines (IL-1 beta, IL-6, TNF-alpha, and IL-10) and inhibited the activation of the NF-kappa B signaling pathway in mice with lipopolysaccharide (LPS)-induced ARDS. Further analysis indicated that Nef provided protection against endothelial glycocalyx degradation in LPS-induced ARDS mice (in vivo) and in LPS-stimulated human umbilical vein endothelial cells (in vitro). The glycocalyx-protective effect of Nef may be initiated by suppressing the production of mitochondrial ROS (mtROS) and decreasing oxidative damage. Nef was also found to promote glycocalyx restoration by accelerating the removal of mtROS in endothelial cells in LPS-induced ARDS. These results suggested the potential of Nef as a therapeutic agent for ARDS associated with Gram-negative bacterial infections and elucidated the mechanisms underlying the protection and restoration of the endothelial glycocalyx.
关键词Nf-kappa-b Hepatic Ischemia/reperfusion Injury Lotus Seed Embryo Acute Lung Injury Cells Activation Apoptosis Pathway Sepsis Permeability
DOI10.3389/fphys.2018.00102
收录类别SCI
语种英语
WOS记录号WOS:000425779900001
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29083
专题中科院上海应用物理研究所2011-2018年
作者单位1.Liu, XY
2.Xu, HX
3.Li, JK
4.Zhang, D
5.Ma, XH
6.Huang, LN
7.Lu, JH
8.Wang, XZ
推荐引用方式
GB/T 7714
Liu, XY,Xu, HX,Li, JK,et al. Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome[J]. FRONTIERS IN PHYSIOLOGY,2018,9:-.
APA Liu, XY.,Xu, HX.,Li, JK.,Zhang, D.,Ma, XH.,...&Wang, XZ.(2018).Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.FRONTIERS IN PHYSIOLOGY,9,-.
MLA Liu, XY,et al."Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome".FRONTIERS IN PHYSIOLOGY 9(2018):-.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Neferine Protects En(11417KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, XY]的文章
[Xu, HX]的文章
[Li, JK]的文章
百度学术
百度学术中相似的文章
[Liu, XY]的文章
[Xu, HX]的文章
[Li, JK]的文章
必应学术
必应学术中相似的文章
[Liu, XY]的文章
[Xu, HX]的文章
[Li, JK]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。