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pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time
Jiang, ZQ; Tian, YC; Shan, DY; Wang, YJ; Gerhard, E; Xia, JB; Huang, R; He, Y; Li, AG; Tang, JC; Ruan, HM; Li, Y; Li, J; Yang, J; Wu, AG
2018
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume170Pages:70-81
Subtype期刊论文
AbstractNanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y-1 receptor (Y1R) ligand modified, photo luminescent BPLP nanobubbles and nanoparticles for targeted breast cancer ultrasound imaging; however, increased accumulation could also be observed in the liver, kidney, and spleen, suggesting significant interaction of the particles with macrophages in vivo. Herein, for the first time, we imparted antiphagocytosis capability to Y1R ligand functionalized BPLP-WPU polymeric micelles through the incorporation of a CD47 human glycoprotein based self-peptide. Application of self-peptide modified, DOX loaded micelles in vivo resulted in a 100% survival rate and complete tumor necrosis over 100 days of treatment. In vivo imaging of SPION loaded, self-peptide modified micelles revealed effective targeting to the tumor site while analysis of iron content demonstrated reduced particle accumulation in the liver and kidney, demonstrating reduced macrophage interaction, as well as a 2-fold increase of particles in the tumor. As these results demonstrate, Y1R ligand, self-peptide modified BPLP-WPU micelles are capable of target specific cancer treatment and imaging, making them ideal candidates to improve survival rate and tumor reduction clinically. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordNeuropeptide-y Analog Drug-delivery Breast-cancer In-vivo Photodynamic Therapy Combination Therapy Antitumor-activity Sensitive Peptide Anticancer Drug Cellular Uptake
DOI10.1016/j.biomaterials.2018.04.002
Indexed BySCI
Language英语
WOS IDWOS:000432903300007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29100
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Jiang, ZQ
2.Tian, YC
3.Shan, DY
4.Wang, YJ
5.Gerhard, E
6.Xia, JB
7.Huang, R
8.He, Y
9.Li, AG
10.Tang, JC
11.Ruan, HM
12.Li, Y
13.Li, J
14.Yang, J
15.Wu, AG
Recommended Citation
GB/T 7714
Jiang, ZQ,Tian, YC,Shan, DY,et al. pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time[J]. BIOMATERIALS,2018,170:70-81.
APA Jiang, ZQ.,Tian, YC.,Shan, DY.,Wang, YJ.,Gerhard, E.,...&Wu, AG.(2018).pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time.BIOMATERIALS,170,70-81.
MLA Jiang, ZQ,et al."pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time".BIOMATERIALS 170(2018):70-81.
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