Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery
Chen, HB; Fang, XF; Jin, Y; Hu, X; Yin, M; Men, XJ; Chen, N; Fan, CH; Chiu, DT; Wan, YZ; Wu, CF
2018
发表期刊SMALL
ISSN1613-6810
卷号14期号:21页码:-
文章类型期刊论文
摘要Nanocavities composed of lipids and block polymers have demonstrated great potential in biomedical applications such as sensors, nanoreactors, and delivery vectors. However, it remains a great challenge to produce nanocavities from fluorescent semiconducting polymers owing to their hydrophobic rigid polymer backbones. Here, we describe a facile, yet general strategy that combines photocrosslinking with nanophase separation to fabricate multicolor, water-dispersible semiconducting polymer nanocavities (PNCs). A photocrosslinkable semiconducting polymer is blended with a porogen such as degradable macromolecule to form compact polymer dots (Pdots). After crosslinking the polymer and removing the porogen, this approach yields semiconducting polymer nanospheres with open cavities that are tunable in diameter. Both small molecules and macromolecules can be loaded in the nanocavities, where molecular size can be differentiated by the efficiency of the energy transfer from host polymer to guest molecules. An anticancer drug doxorubicin (Dox) is loaded into the nanocavities and the intracellular release is monitored in real time by the fluorescence signal. Finally, the efficient delivery of small interfering RNA (siRNA) to silence gene expression without affecting cell viability is demonstrated. The combined features of bright fluorescence, tunable cavity, and efficient drug/siRNA delivery makes these nanostructures promising for biomedical imaging and drug delivery.
关键词Conjugated Polymers Cancer-therapy Metal Nanostructures Photothermal Therapy Hollow Interiors Energy-transfer Drug-delivery Nanoparticles Dots Sirna
DOI10.1002/smll.201800239
收录类别SCI
语种英语
WOS记录号WOS:000434173300016
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29129
专题中科院上海应用物理研究所2011-2018年
作者单位1.Chen, HB
2.Fang, XF
3.Jin, Y
4.Hu, X
5.Yin, M
6.Men, XJ
7.Chen, N
8.Fan, CH
9.Chiu, DT
10.Wan, YZ
11.Wu, CF
推荐引用方式
GB/T 7714
Chen, HB,Fang, XF,Jin, Y,et al. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery[J]. SMALL,2018,14(21):-.
APA Chen, HB.,Fang, XF.,Jin, Y.,Hu, X.,Yin, M.,...&Wu, CF.(2018).Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.SMALL,14(21),-.
MLA Chen, HB,et al."Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery".SMALL 14.21(2018):-.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Semiconducting Polym(5398KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, HB]的文章
[Fang, XF]的文章
[Jin, Y]的文章
百度学术
百度学术中相似的文章
[Chen, HB]的文章
[Fang, XF]的文章
[Jin, Y]的文章
必应学术
必应学术中相似的文章
[Chen, HB]的文章
[Fang, XF]的文章
[Jin, Y]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Semiconducting Polymer Nanocavities_ Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug_siRNA Delivery.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。