CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery
Chen, HB; Fang, XF; Jin, Y; Hu, X; Yin, M; Men, XJ; Chen, N; Fan, CH; Chiu, DT; Wan, YZ; Wu, CF
2018
Source PublicationSMALL
ISSN1613-6810
Volume14Issue:21Pages:-
Subtype期刊论文
AbstractNanocavities composed of lipids and block polymers have demonstrated great potential in biomedical applications such as sensors, nanoreactors, and delivery vectors. However, it remains a great challenge to produce nanocavities from fluorescent semiconducting polymers owing to their hydrophobic rigid polymer backbones. Here, we describe a facile, yet general strategy that combines photocrosslinking with nanophase separation to fabricate multicolor, water-dispersible semiconducting polymer nanocavities (PNCs). A photocrosslinkable semiconducting polymer is blended with a porogen such as degradable macromolecule to form compact polymer dots (Pdots). After crosslinking the polymer and removing the porogen, this approach yields semiconducting polymer nanospheres with open cavities that are tunable in diameter. Both small molecules and macromolecules can be loaded in the nanocavities, where molecular size can be differentiated by the efficiency of the energy transfer from host polymer to guest molecules. An anticancer drug doxorubicin (Dox) is loaded into the nanocavities and the intracellular release is monitored in real time by the fluorescence signal. Finally, the efficient delivery of small interfering RNA (siRNA) to silence gene expression without affecting cell viability is demonstrated. The combined features of bright fluorescence, tunable cavity, and efficient drug/siRNA delivery makes these nanostructures promising for biomedical imaging and drug delivery.
KeywordConjugated Polymers Cancer-therapy Metal Nanostructures Photothermal Therapy Hollow Interiors Energy-transfer Drug-delivery Nanoparticles Dots Sirna
DOI10.1002/smll.201800239
Indexed BySCI
Language英语
WOS IDWOS:000434173300016
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29129
Collection中科院上海应用物理研究所2011-2019年
Affiliation1.Chen, HB
2.Fang, XF
3.Jin, Y
4.Hu, X
5.Yin, M
6.Men, XJ
7.Chen, N
8.Fan, CH
9.Chiu, DT
10.Wan, YZ
11.Wu, CF
Recommended Citation
GB/T 7714
Chen, HB,Fang, XF,Jin, Y,et al. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery[J]. SMALL,2018,14(21):-.
APA Chen, HB.,Fang, XF.,Jin, Y.,Hu, X.,Yin, M.,...&Wu, CF.(2018).Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.SMALL,14(21),-.
MLA Chen, HB,et al."Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery".SMALL 14.21(2018):-.
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