Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery

doi:10.1002/smll.201800239

CAS OpenIR > 中科院上海应用物理研究所2011-2018年

	Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery
	Chen, HB ; Fang, XF ; Jin, Y ; Hu, X ; Yin, M ; Men, XJ ; Chen, N ; Fan, CH ; Chiu, DT ; Wan, YZ ; Wu, CF
	2018
发表期刊	SMALL
ISSN	1613-6810
卷号	14 期号:21 页码:-
文章类型	期刊论文
摘要	Nanocavities composed of lipids and block polymers have demonstrated great potential in biomedical applications such as sensors, nanoreactors, and delivery vectors. However, it remains a great challenge to produce nanocavities from fluorescent semiconducting polymers owing to their hydrophobic rigid polymer backbones. Here, we describe a facile, yet general strategy that combines photocrosslinking with nanophase separation to fabricate multicolor, water-dispersible semiconducting polymer nanocavities (PNCs). A photocrosslinkable semiconducting polymer is blended with a porogen such as degradable macromolecule to form compact polymer dots (Pdots). After crosslinking the polymer and removing the porogen, this approach yields semiconducting polymer nanospheres with open cavities that are tunable in diameter. Both small molecules and macromolecules can be loaded in the nanocavities, where molecular size can be differentiated by the efficiency of the energy transfer from host polymer to guest molecules. An anticancer drug doxorubicin (Dox) is loaded into the nanocavities and the intracellular release is monitored in real time by the fluorescence signal. Finally, the efficient delivery of small interfering RNA (siRNA) to silence gene expression without affecting cell viability is demonstrated. The combined features of bright fluorescence, tunable cavity, and efficient drug/siRNA delivery makes these nanostructures promising for biomedical imaging and drug delivery.
关键词	Conjugated Polymers Cancer-therapy Metal Nanostructures Photothermal Therapy Hollow Interiors Energy-transfer Drug-delivery Nanoparticles Dots Sirna
DOI	10.1002/smll.201800239
收录类别	SCI
语种	英语
WOS记录号	WOS:000434173300016
引用统计
文献类型	期刊论文
条目标识符	http://ir.sinap.ac.cn/handle/331007/29129
专题	中科院上海应用物理研究所2011-2018年
作者单位	1.Chen, HB 2.Fang, XF 3.Jin, Y 4.Hu, X 5.Yin, M 6.Men, XJ 7.Chen, N 8.Fan, CH 9.Chiu, DT 10.Wan, YZ 11.Wu, CF
推荐引用方式 GB/T 7714	Chen, HB,Fang, XF,Jin, Y,et al. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery[J]. SMALL,2018,14(21):-.
APA	Chen, HB.,Fang, XF.,Jin, Y.,Hu, X.,Yin, M.,...&Wu, CF.(2018).Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery.SMALL,14(21),-.
MLA	Chen, HB,et al."Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host-Guest Interactions, and Enhanced Drug/siRNA Delivery".SMALL 14.21(2018):-.

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