Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor
Zhang, Y; Shuai, ZH; Zhou, H; Luo, ZM; Liu, B; Zhang, YN; Zhang, L; Chen, SF; Chao, J; Weng, LM; Fan, QL; Fan, CH; Huang, W; Wang, LH
2018
发表期刊JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
卷号140期号:11页码:3988-3993
文章类型期刊论文
摘要Analysis of biomolecules at the single-molecule level is a great challenge in molecular diagnostics, gene profiling, and environmental monitoring. In this work, we design a smart plasmonic nanobiosensor based on individual Au@Ag core-shell nanocube (Au@Ag NC) modified with tetrahedron-structured DNA (tsDNA) for detecting microRNA 21 (miR-21) at the single-molecule level. An average localized surface plasmon resonance (LSPR) scattering spectral wavelength shift of approximately 0.4 nm can be obtained for a single miR-21 hybridization event on the nanobiosensor. In addition, the sensing mechanism of the individual Au@Ag NC is further verified by the three-dimensional finite-difference time-domain (3D-FDTD) simulations. Notably, this system not only allows the real-time detection of miR-21 with an aM level sensitivity over a large dynamic range from 1 aM to 1 nM, but also enables DNA-based logic operations as well as biomemory by exploiting miR-21, KpnI, and StuI-responsive assays. Our study opens a unique method for single-molecule detection of biomolecules and thus holds great promise in a variety of biological and biomedical applications.
关键词Core-shell Nanocubes Silver Nanoparticles Gold Nanoparticles Dna Nanostructure Au Surface Nanoprobes Biosensors Platform Sensors
DOI10.1021/jacs.7b12772
收录类别SCI
语种英语
WOS记录号WOS:000428356000028
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29138
专题中科院上海应用物理研究所2011-2018年
作者单位1.Zhang, Y
2.Shuai, ZH
3.Zhou, H
4.Luo, ZM
5.Liu, B
6.Zhang, YN
7.Zhang, L
8.Chen, SF
9.Chao, J
10.Weng, LM
11.Fan, QL
12.Fan, CH
13.Huang, W
14.Wang, LH
推荐引用方式
GB/T 7714
Zhang, Y,Shuai, ZH,Zhou, H,et al. Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(11):3988-3993.
APA Zhang, Y.,Shuai, ZH.,Zhou, H.,Luo, ZM.,Liu, B.,...&Wang, LH.(2018).Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(11),3988-3993.
MLA Zhang, Y,et al."Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.11(2018):3988-3993.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Single-Molecule Anal(3488KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Y]的文章
[Shuai, ZH]的文章
[Zhou, H]的文章
百度学术
百度学术中相似的文章
[Zhang, Y]的文章
[Shuai, ZH]的文章
[Zhou, H]的文章
必应学术
必应学术中相似的文章
[Zhang, Y]的文章
[Shuai, ZH]的文章
[Zhou, H]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。