Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure
Xia, K; Kong, HT; Cui, YZ; Ren, N; Li, QN; Ma, JF; Cui, RR; Zhang, Y; Shi, JY; Li, Q; Lv, M; Sun, YH; Wang, LH; Li, J; Zhu, Y
2018
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号10期号:18页码:15442-15448
文章类型期刊论文
摘要The advent of DNA technology has demonstrated great potential in a wide range of applications, especially in the field of biology and biomedicine. However, current understanding of the toxicological effects and cellular responses of DNA nanostructures remains to be improved. Here, we chose tetrahedral DNA nanostructures (TDNs), a type of nanocarriers for delivering molecular drugs, as a model for systematic live-cell analysis of the biocompatibility of TDNs to normal bronchial epithelial cells, carcinoma cells, and macrophage. We found that the interaction behaviors of TDNs in different cell lines were very different, whereas after internalization, most of the TDNs in diverse cell lines were positioned to lysosomes. By a systematic assessment of cell responses after TDN exposure to various cells, we demonstrate that internalized TDNs have good innate biocompatibility. Interestingly, we found that TDN-bearing cells would not affect the cell cycle progression and accompany cell division and that TDNs were separated equally into two daughter cells. This study improves our understanding of the interaction of DNA nanostructures with living systems and their biocompatibility, which will be helpful for further designing DNA nanostructures for biomedical applications.
关键词Drug-delivery Nanoparticle-uptake Gold Nanoparticles Origami Nanotechnology Accumulation Resistance Pathways Carrier Range
DOI10.1021/acsami.8b02626
收录类别SCI
语种英语
WOS记录号WOS:000432205800014
引用统计
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29164
专题中科院上海应用物理研究所2011-2018年
作者单位1.Xia, K
2.Kong, HT
3.Cui, YZ
4.Ren, N
5.Li, QN
6.Ma, JF
7.Cui, RR
8.Zhang, Y
9.Shi, JY
10.Li, Q
11.Lv, M
12.Sun, YH
13.Wang, LH
14.Li, J
15.Zhu, Y
推荐引用方式
GB/T 7714
Xia, K,Kong, HT,Cui, YZ,et al. Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(18):15442-15448.
APA Xia, K.,Kong, HT.,Cui, YZ.,Ren, N.,Li, QN.,...&Zhu, Y.(2018).Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure.ACS APPLIED MATERIALS & INTERFACES,10(18),15442-15448.
MLA Xia, K,et al."Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure".ACS APPLIED MATERIALS & INTERFACES 10.18(2018):15442-15448.
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