CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure
Xia, K; Kong, HT; Cui, YZ; Ren, N; Li, QN; Ma, JF; Cui, RR; Zhang, Y; Shi, JY; Li, Q; Lv, M; Sun, YH; Wang, LH; Li, J; Zhu, Y
2018
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:18Pages:15442-15448
Subtype期刊论文
AbstractThe advent of DNA technology has demonstrated great potential in a wide range of applications, especially in the field of biology and biomedicine. However, current understanding of the toxicological effects and cellular responses of DNA nanostructures remains to be improved. Here, we chose tetrahedral DNA nanostructures (TDNs), a type of nanocarriers for delivering molecular drugs, as a model for systematic live-cell analysis of the biocompatibility of TDNs to normal bronchial epithelial cells, carcinoma cells, and macrophage. We found that the interaction behaviors of TDNs in different cell lines were very different, whereas after internalization, most of the TDNs in diverse cell lines were positioned to lysosomes. By a systematic assessment of cell responses after TDN exposure to various cells, we demonstrate that internalized TDNs have good innate biocompatibility. Interestingly, we found that TDN-bearing cells would not affect the cell cycle progression and accompany cell division and that TDNs were separated equally into two daughter cells. This study improves our understanding of the interaction of DNA nanostructures with living systems and their biocompatibility, which will be helpful for further designing DNA nanostructures for biomedical applications.
KeywordDrug-delivery Nanoparticle-uptake Gold Nanoparticles Origami Nanotechnology Accumulation Resistance Pathways Carrier Range
DOI10.1021/acsami.8b02626
Indexed BySCI
Language英语
WOS IDWOS:000432205800014
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29164
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Xia, K
2.Kong, HT
3.Cui, YZ
4.Ren, N
5.Li, QN
6.Ma, JF
7.Cui, RR
8.Zhang, Y
9.Shi, JY
10.Li, Q
11.Lv, M
12.Sun, YH
13.Wang, LH
14.Li, J
15.Zhu, Y
Recommended Citation
GB/T 7714
Xia, K,Kong, HT,Cui, YZ,et al. Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(18):15442-15448.
APA Xia, K.,Kong, HT.,Cui, YZ.,Ren, N.,Li, QN.,...&Zhu, Y.(2018).Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure.ACS APPLIED MATERIALS & INTERFACES,10(18),15442-15448.
MLA Xia, K,et al."Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure".ACS APPLIED MATERIALS & INTERFACES 10.18(2018):15442-15448.
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