CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe
Tian, T; Li, J; Xie, C; Sun, YH; Lei, HZ; Liu, XY; Xia, JY; Shi, JY; Wang, LH; Lu, WY; Fan, CH
AbstractDevelopment of agents for delivering drugs and imaging probes across the blood brain barrier (BBB) remains a major challenge. In this study, we designed a biocompatible framework nucleic acid (FNA)-based imaging probe for brain tumor-targeting. We employed a typical type of FNAs, tetrahedral DNA nanostructures (TDNs), as the building block, which were modified with angiopep-2 (ANG), a 19-mer peptide derived from human Kunitz domain of aprotinin. This probe exhibited high binding efficiency with low-density lipoprotein receptor-related protein-1 (LRP-1) of BBB and glioma. We found that ANG-functionalized TDNs (ANG-TDNs) stayed intact for at least 12 h in serum, and that ANG modification effectively enhanced cellular uptake of TDNs in brain capillary endothelial cells and Uppsala 87 malignant glioma (U87MG) cells. Remarkably, studies in both in vitro and in vivo models revealed that ANG-TDNs could cross the BBB. Especially, in vivo imaging showed strong fluorescent signals in U87MG human glioblastoma xenograft in nude mice. This study establishes that the FNA-based platform provides a new theranostic tool for the study and therapy of brain tumors.
KeywordReceptor-mediated Transcytosis Dna Nanostructures Delivery Barrier Nanoparticles Angiopep-2 Peptides Origami
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WOS IDWOS:000424728800030
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Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Tian, T
2.Li, J
3.Xie, C
4.Sun, YH
5.Lei, HZ
6.Liu, XY
7.Xia, JY
8.Shi, JY
9.Wang, LH
10.Lu, WY
11.Fan, CH
Recommended Citation
GB/T 7714
Tian, T,Li, J,Xie, C,et al. Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(4):3414-3420.
APA Tian, T.,Li, J.,Xie, C.,Sun, YH.,Lei, HZ.,...&Fan, CH.(2018).Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe.ACS APPLIED MATERIALS & INTERFACES,10(4),3414-3420.
MLA Tian, T,et al."Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe".ACS APPLIED MATERIALS & INTERFACES 10.4(2018):3414-3420.
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