Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe
Tian, T; Li, J; Xie, C; Sun, YH; Lei, HZ; Liu, XY; Xia, JY; Shi, JY; Wang, LH; Lu, WY; Fan, CH
2018
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号10期号:4页码:3414-3420
文章类型期刊论文
摘要Development of agents for delivering drugs and imaging probes across the blood brain barrier (BBB) remains a major challenge. In this study, we designed a biocompatible framework nucleic acid (FNA)-based imaging probe for brain tumor-targeting. We employed a typical type of FNAs, tetrahedral DNA nanostructures (TDNs), as the building block, which were modified with angiopep-2 (ANG), a 19-mer peptide derived from human Kunitz domain of aprotinin. This probe exhibited high binding efficiency with low-density lipoprotein receptor-related protein-1 (LRP-1) of BBB and glioma. We found that ANG-functionalized TDNs (ANG-TDNs) stayed intact for at least 12 h in serum, and that ANG modification effectively enhanced cellular uptake of TDNs in brain capillary endothelial cells and Uppsala 87 malignant glioma (U87MG) cells. Remarkably, studies in both in vitro and in vivo models revealed that ANG-TDNs could cross the BBB. Especially, in vivo imaging showed strong fluorescent signals in U87MG human glioblastoma xenograft in nude mice. This study establishes that the FNA-based platform provides a new theranostic tool for the study and therapy of brain tumors.
关键词Receptor-mediated Transcytosis Dna Nanostructures Delivery Barrier Nanoparticles Angiopep-2 Peptides Origami
DOI10.1021/acsami.7b17927
收录类别SCI
语种英语
WOS记录号WOS:000424728800030
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29166
专题中科院上海应用物理研究所2011-2018年
作者单位1.Tian, T
2.Li, J
3.Xie, C
4.Sun, YH
5.Lei, HZ
6.Liu, XY
7.Xia, JY
8.Shi, JY
9.Wang, LH
10.Lu, WY
11.Fan, CH
推荐引用方式
GB/T 7714
Tian, T,Li, J,Xie, C,et al. Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(4):3414-3420.
APA Tian, T.,Li, J.,Xie, C.,Sun, YH.,Lei, HZ.,...&Fan, CH.(2018).Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe.ACS APPLIED MATERIALS & INTERFACES,10(4),3414-3420.
MLA Tian, T,et al."Targeted Imaging of Brain Tumors with a Framework Nucleic Acid Probe".ACS APPLIED MATERIALS & INTERFACES 10.4(2018):3414-3420.
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