CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Valency-Controlled Framework Nucleic Acid Signal Amplifiers
Liu, Q; Ge, ZL; Mao, XH; Zhou, GB; Zuo, XL; Shen, JW; Shi, JY; Li, J; Wang, LH; Chen, XQ; Fan, CH
AbstractWeak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in invitro biomimetic systems generally lack the spatiotemporal regulation invivo. Herein we report a framework nucleic acid (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins, and inorganic nanoparticles in a stoichiometric manner. The valence-controlled signal amplifier enhanced the quantification ability of electrochemical biosensors, and enabled ultrasensitive detection of tumor-relevant circulating free DNA (cfDNA) with sensitivity enhancement of 3-5 orders of magnitude and improved dynamic range.
KeywordHybridization Chain-reaction Tetrahedral Dna Nanostructure Gold Nanoparticles Messenger-rna Electrochemical Detection Inorganic Nanomaterials Reaction Amplification Biomolecular Detection Biosensing Interface Gene-expression
Indexed BySCI
WOS IDWOS:000434350400027
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Document Type期刊论文
Affiliation1.Liu, Q
2.Ge, ZL
3.Mao, XH
4.Zhou, GB
5.Zuo, XL
6.Shen, JW
7.Shi, JY
8.Li, J
9.Wang, LH
10.Chen, XQ
11.Fan, CH
Recommended Citation
GB/T 7714
Liu, Q,Ge, ZL,Mao, XH,et al. Valency-Controlled Framework Nucleic Acid Signal Amplifiers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(24):7131-7135.
APA Liu, Q.,Ge, ZL.,Mao, XH.,Zhou, GB.,Zuo, XL.,...&Fan, CH.(2018).Valency-Controlled Framework Nucleic Acid Signal Amplifiers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(24),7131-7135.
MLA Liu, Q,et al."Valency-Controlled Framework Nucleic Acid Signal Amplifiers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.24(2018):7131-7135.
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