Valency-Controlled Framework Nucleic Acid Signal Amplifiers
Liu, Q; Ge, ZL; Mao, XH; Zhou, GB; Zuo, XL; Shen, JW; Shi, JY; Li, J; Wang, LH; Chen, XQ; Fan, CH
2018
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号57期号:24页码:7131-7135
文章类型期刊论文
摘要Weak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in invitro biomimetic systems generally lack the spatiotemporal regulation invivo. Herein we report a framework nucleic acid (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins, and inorganic nanoparticles in a stoichiometric manner. The valence-controlled signal amplifier enhanced the quantification ability of electrochemical biosensors, and enabled ultrasensitive detection of tumor-relevant circulating free DNA (cfDNA) with sensitivity enhancement of 3-5 orders of magnitude and improved dynamic range.
关键词Hybridization Chain-reaction Tetrahedral Dna Nanostructure Gold Nanoparticles Messenger-rna Electrochemical Detection Inorganic Nanomaterials Reaction Amplification Biomolecular Detection Biosensing Interface Gene-expression
DOI10.1002/anie.201802701
收录类别SCI
语种英语
WOS记录号WOS:000434350400027
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sinap.ac.cn/handle/331007/29206
专题中科院上海应用物理研究所2011-2018年
作者单位1.Liu, Q
2.Ge, ZL
3.Mao, XH
4.Zhou, GB
5.Zuo, XL
6.Shen, JW
7.Shi, JY
8.Li, J
9.Wang, LH
10.Chen, XQ
11.Fan, CH
推荐引用方式
GB/T 7714
Liu, Q,Ge, ZL,Mao, XH,et al. Valency-Controlled Framework Nucleic Acid Signal Amplifiers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(24):7131-7135.
APA Liu, Q.,Ge, ZL.,Mao, XH.,Zhou, GB.,Zuo, XL.,...&Fan, CH.(2018).Valency-Controlled Framework Nucleic Acid Signal Amplifiers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(24),7131-7135.
MLA Liu, Q,et al."Valency-Controlled Framework Nucleic Acid Signal Amplifiers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.24(2018):7131-7135.
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