CAS OpenIR  > 中科院上海应用物理研究所2011-2018年
Valency-Controlled Framework Nucleic Acid Signal Amplifiers
Liu, Q; Ge, ZL; Mao, XH; Zhou, GB; Zuo, XL; Shen, JW; Shi, JY; Li, J; Wang, LH; Chen, XQ; Fan, CH
2018
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:24Pages:7131-7135
Subtype期刊论文
AbstractWeak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in invitro biomimetic systems generally lack the spatiotemporal regulation invivo. Herein we report a framework nucleic acid (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins, and inorganic nanoparticles in a stoichiometric manner. The valence-controlled signal amplifier enhanced the quantification ability of electrochemical biosensors, and enabled ultrasensitive detection of tumor-relevant circulating free DNA (cfDNA) with sensitivity enhancement of 3-5 orders of magnitude and improved dynamic range.
KeywordHybridization Chain-reaction Tetrahedral Dna Nanostructure Gold Nanoparticles Messenger-rna Electrochemical Detection Inorganic Nanomaterials Reaction Amplification Biomolecular Detection Biosensing Interface Gene-expression
DOI10.1002/anie.201802701
Indexed BySCI
Language英语
WOS IDWOS:000434350400027
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/29206
Collection中科院上海应用物理研究所2011-2018年
Affiliation1.Liu, Q
2.Ge, ZL
3.Mao, XH
4.Zhou, GB
5.Zuo, XL
6.Shen, JW
7.Shi, JY
8.Li, J
9.Wang, LH
10.Chen, XQ
11.Fan, CH
Recommended Citation
GB/T 7714
Liu, Q,Ge, ZL,Mao, XH,et al. Valency-Controlled Framework Nucleic Acid Signal Amplifiers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(24):7131-7135.
APA Liu, Q.,Ge, ZL.,Mao, XH.,Zhou, GB.,Zuo, XL.,...&Fan, CH.(2018).Valency-Controlled Framework Nucleic Acid Signal Amplifiers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(24),7131-7135.
MLA Liu, Q,et al."Valency-Controlled Framework Nucleic Acid Signal Amplifiers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.24(2018):7131-7135.
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