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Anomalous behavior of membrane fluidity caused by copper-copper bond coupled phospholipids
Jiang, XK; Zhang, JJ; Zhou, B; Li, P; Hu, XJ; Zhu, Z; Tan, YW; Chang, C; Lu, JH; Song, B
2018
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume8Issue:-Pages:-
Subtype期刊论文
AbstractMembrane fluidity, essential for cell functions, is obviously affected by copper, but the molecular mechanism is poorly understood. Here, we unexpectedly observed that a decrease in phospholipid (PL) bilayer fluidity caused by Cu2+ was more significant than those by Zn2+ and Ca2+, while a comparable reduction occurred in the last two ions. This finding disagrees with the placement in the periodic table of Cu just next to Zn and far from Ca. The physical nature was revealed to be an anomalous attraction between Cu(+ )cations, as well as the induced motif of two phospholipids coupled by Cu-Cu bond (PL-diCu-PL). Namely, upon Cu2+ ion binding to a negatively charged phosphate group of lipid, Cu2+ was reduced to Cu+. The attraction of the cations then caused one Cu+ ion simultaneously binding to two lipids and another Cu+, resulting in the formation of PL-diCu-PL structure. In contrast, this attraction cannot occur in the cases of Zn and Ca ions. Remarkably, besides lipids, the phosphate group also widely exists in other biological molecules, including DNA, RNA, ADP and ATP. Our findings thus provide a new view for understanding the biological functions of copper and the mechanism underlying copper-related diseases, as well as lipid assembly.
KeywordADDITIVE FORCE-FIELD PARTICLE MESH EWALD LIPID-MEMBRANES LIQUID WATER DYNAMICS IONS PHOSPHATIDYLCHOLINE SHELL CU2+ PHOSPHATIDYLETHANOLAMINE
DOI10.1038/s41598-018-32322-4
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/30847
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Changzhou Inst Technol, Sch Math Sci & Chem Engn, Changzhou 213032, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
4.Chengdu Technol Univ, Sch Elect Engn, Chengdu 611730, Sichuan, Peoples R China
5.Fudan Univ, State Key Lab Surface Phys, Shanghai 200433, Peoples R China
6.Fudan Univ, Dept Phys, Shanghai 200433, Peoples R China
7.Univ Shanghai Sci & Technol, Sch Opt Elect Comp Engn, Terahertz Technol Innovat Res Inst, Shanghai Key Lab Modern Opt Syst,Terahertz Sci Co, Shanghai 200093, Peoples R China
8.Xi An Jiao Tong Univ, Minist Educ, Key Lab Phys Elect & Devices, Xian 710049, Peoples R China
Recommended Citation
GB/T 7714
Jiang, XK,Zhang, JJ,Zhou, B,et al. Anomalous behavior of membrane fluidity caused by copper-copper bond coupled phospholipids[J]. SCIENTIFIC REPORTS,2018,8(-):-.
APA Jiang, XK.,Zhang, JJ.,Zhou, B.,Li, P.,Hu, XJ.,...&Song, B.(2018).Anomalous behavior of membrane fluidity caused by copper-copper bond coupled phospholipids.SCIENTIFIC REPORTS,8(-),-.
MLA Jiang, XK,et al."Anomalous behavior of membrane fluidity caused by copper-copper bond coupled phospholipids".SCIENTIFIC REPORTS 8.-(2018):-.
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