CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Complex silica composite nanomaterials templated with DNA origami
Liu, XG; Zhang, F; Jing, XX; Pan, MC; Liu, P; Li, W; Zhu, BW; Li, J; Chen, H; Wang, LH; Lin, JP; Liu, Y; Zhao, DY; Yan, H; Fan, CH
2018
Source PublicationNATURE
ISSN0028-0836
Volume559Issue:7715Pages:593-598
Subtype期刊论文
AbstractGenetically encoded protein scaffolds often serve as templates for the mineralization of biocomposite materials with complex yet highly controlled structural features that span from nanometres to the macroscopic scale(1-4). Methods developed to mimic these fabrication capabilities can produce synthetic materials with well defined micro-and macro-sized features, but extending control to the nanoscale remains challenging(5,6). DNA nanotechnology can deliver a wide range of customized nanoscale two-and three-dimensional assemblies with controlled sizes and shapes(7-11). But although DNA has been used to modulate the morphology of inorganic materials(12,13) and DNA nanostructures have served as moulds(14,15) and templates(16,17), it remains challenging to exploit the potential of DNA nanostructures fully because they require high-ionic-strength solutions to maintain their structure, and this in turn gives rise to surface charging that suppresses the material deposition. Here we report that the Stober method, widely used for producing silica (silicon dioxide) nanostructures, can be adjusted to overcome this difficulty: when synthesis conditions are such that mineral precursor molecules do not deposit directly but first form clusters, DNA-silica hybrid materials that faithfully replicate the complex geometric information of a wide range of different DNA origami scaffolds are readily obtained. We illustrate this approach using frame-like, curved and porous DNA nanostructures, with one-, two- and three-dimensional complex hierarchical architectures that range in size from 10 to 1,000 nanometres. We also show that after coating with an amorphous silica layer, the thickness of which can be tuned by adjusting the growth time, hybrid structures can be up to ten times tougher than the DNA template while maintaining flexibility. These findings establish our approach as a general method for creating biomimetic silica nanostructures.
KeywordCRYSTAL NANOSCALE MOLECULES NANOFABRICATION NANOSTRUCTURE ORIENTATION ELASTICITY MECHANICS STRATEGY SHAPES
DOI10.1038/s41586-018-0332-7
Indexed BySCI
Language英语
Citation statistics
Cited Times:74[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/30880
Collection中科院上海应用物理研究所2011-2019年
Affiliation1.Chinese Acad Sci, Univ Chinese Acad Sci, Div Phys Biol, Shanghai, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,CAS Key Lab Interfacial P, Shanghai, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai, Peoples R China
5.Biodesign Inst, Ctr Mol Design & Biomimet, Tempe, AZ 85281 USA
6.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85281 USA
7.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk, Tianjin, Peoples R China
8.Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk, Tianjin, Peoples R China
9.Chinese Acad Sci, Biodesign Ctr, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China
10.Fudan Univ, Dept Chem, Adv Mat Lab, Shanghai Key Lab Mol Catalysis & Innovat Mat,iChE, Shanghai, Peoples R China
11.Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China
12.East China Normal Univ, Sch chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai, Peoples R China
13.Xiamen Univ, Pen Tung Sah Inst Micronano Sci & Technol, Xiamen, Peoples R China
Recommended Citation
GB/T 7714
Liu, XG,Zhang, F,Jing, XX,et al. Complex silica composite nanomaterials templated with DNA origami[J]. NATURE,2018,559(7715):593-598.
APA Liu, XG.,Zhang, F.,Jing, XX.,Pan, MC.,Liu, P.,...&Fan, CH.(2018).Complex silica composite nanomaterials templated with DNA origami.NATURE,559(7715),593-598.
MLA Liu, XG,et al."Complex silica composite nanomaterials templated with DNA origami".NATURE 559.7715(2018):593-598.
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