CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Serum protein corona-responsive autophagy tuning in cells
Kong, HT; Xia, K; Ren, N; Cui, YZ; Liu, RD; Li, QN; Lv, M; Shi, JY; Yan, QL; Cui, ZF; Fan, CH; Zhu, Y; Wang, LH
2018
Source PublicationNANOSCALE
ISSN2040-3364
Volume10Issue:37Pages:18055-18063
Subtype期刊论文
AbstractAutophagy represents an important cellular response to nanoparticles (NPs), whose modulation holds great promise for developing nanomedicine. Here, we systematically studied cell autophagy responses elicited by the NP-protein corona with diverse protein corona types surrounding NPs with different sizes, shapes, and compositions. We demonstrated that these physicochemical properties of NP-protein coronas exerted a remarkable influence on cell autophagy responses. Particularly, for surface protein type-associated modulation of cell autophagy, we correlated the autophagy level to adsorbed protein type on Fe3O4 NPs. Accordingly, we could modulate cell autophagy in response to various levels of protein adsorption. Our work provides new clues to modulate cell autophagy by rational designing NP-protein complexes, which could aid in further biological and therapeutic applications.
KeywordCARBON NANOTUBES SILVER NANOPARTICLES QUANTUM DOTS CYTOTOXICITY OXIDE DEPENDENCE CHEMISTRY PEPTIDES DISEASE IMPACT
DOI10.1039/c8nr05770b
Indexed BySCI
Language英语
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31101
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
4.UCB Pharma, 208 Bath Rd, Slough SL1 3WE, Berks, England
Recommended Citation
GB/T 7714
Kong, HT,Xia, K,Ren, N,et al. Serum protein corona-responsive autophagy tuning in cells[J]. NANOSCALE,2018,10(37):18055-18063.
APA Kong, HT.,Xia, K.,Ren, N.,Cui, YZ.,Liu, RD.,...&Wang, LH.(2018).Serum protein corona-responsive autophagy tuning in cells.NANOSCALE,10(37),18055-18063.
MLA Kong, HT,et al."Serum protein corona-responsive autophagy tuning in cells".NANOSCALE 10.37(2018):18055-18063.
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