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Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling
Liu, C; Li, P; Chen, N; Jiang, YG; Shi, JY; Fan, CH; Song, HY
2017
Source PublicationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN1550-7033
Volume13Issue:11Pages:1522-1532
Subtype期刊论文
AbstractBiocompatible nanoparticles (NPs) have been implied in various biological and biomedical applications. However, the effects of nanoscale materials on long term health and disease conditions remain largely unclear. Here, we demonstrate that two types of titanium dioxide NPs (TiO(2)NPs), with primary sizes of 10 nm and 50 nm, inhibit Wnt signaling under in vitro and in vivo contexts. At concentrations without causing cytotoxicity, TiO(2)NPs diminish Wnt-stimulated cancer cell metastasis, weaken the anti-adipogenic effect of Wnt during adipocyte differentiation, and impair Wnt-promoted tail elongation during the development of Zebrafish. Significantly, we find that TiO(2)NPs induce non-canonical endocytic trafficking of the Wnt receptor Lrp6. The reduction in the amount of active Lrp6 for signal transduction prevents the nuclear entry of beta-catenin, a key transcription activator in the Wnt signaling axis, and interferes with the outputs of Wnt signaling. Our study discloses both potential risks and possible benefits for applications of TiO(2)NPs, provides a molecular basis for the interaction between TiO2NPs and cellular signaling, and suggests close connections between natural biological molecules and synthetic NPs.
KeywordBETA-CATENIN PHOTOTHERMAL THERAPY GOLD NANOPARTICLES TIO2 NANOPARTICLES TARGETED DELIVERY INTESTINAL-CELLS DRUG-DELIVERY IRON-OXIDE LRP6 INTERNALIZATION
DOI10.1166/jbn.2017.2458
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31153
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
2.Univ Chinese Acad Sci, Shanghai Inst Appl Phys, Chinese Acad Sci,Div Phys Biol, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China
3.Univ Chinese Acad Sci, Shanghai Inst Appl Phys, Chinese Acad Sci,Bioimaging Ctr, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China
4.Guangzhou Med Univ, Sch Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China
5.UCB Pharma, Slough SL2 3WE, Berks, England
Recommended Citation
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Liu, C,Li, P,Chen, N,et al. Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(11):1522-1532.
APA Liu, C.,Li, P.,Chen, N.,Jiang, YG.,Shi, JY.,...&Song, HY.(2017).Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(11),1522-1532.
MLA Liu, C,et al."Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.11(2017):1522-1532.
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