CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Exploring nanoscale structure change of dermal tissues suffering injury by small angle X-ray scattering and transmission electron microscopy
Jiang, YZ; Tian, F; Wang, ZY; Niu, YW; Yang, JF; Song, F; Jin, SW; Cao, YM; Dong, JY; Lu, SL
2019
Source PublicationMOLECULAR BIOLOGY REPORTS
ISSN0301-4851
Volume46Issue:1Pages:67—76
Subtype期刊论文
AbstractScar formation and wound non-healing often occur during wound repair after skin injury, which are still unresolved. Clinic indicated that the structure played an important role in the wound repair. Our previous research showed that the wound over-healed (scar formation) when the integrity and continuity of dermal tissues was destroyed by injury. Other evidences showed that wound healing was impaired in diabetes because the underlying alternation in their skin tissues occurred caused by advanced glycation end products (AGES) aggregation. In order to explore the changes of the structure of skin at nanoscale, the small angle X-ray scattering (SAXS), compared with transmission electron microscopy (TEM), was applied to observe the skin in different pathological status. The results showed that there were some regular patterns in the structure of dermal tissue. The patterns were changed by different pathological status, which would result in wound healing disorder. These will be beneficial for clarifying the pathological mechanisms of wound healing.
KeywordSKIN SCAR THICKNESS COLLAGEN
DOI10.1007/s11033-018-4444-9
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31619
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai Burns Inst, Shanghai 200025, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China;
3.Shanghai Univ Tradit Chinese Med, Shanghai Tradit Chinese Med Integrated Hosp, Shanghai 200082, Peoples R China;
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Burns & Plast Surg, Shanghai 200025, Peoples R China
Recommended Citation
GB/T 7714
Jiang, YZ,Tian, F,Wang, ZY,et al. Exploring nanoscale structure change of dermal tissues suffering injury by small angle X-ray scattering and transmission electron microscopy[J]. MOLECULAR BIOLOGY REPORTS,2019,46(1):67—76.
APA Jiang, YZ.,Tian, F.,Wang, ZY.,Niu, YW.,Yang, JF.,...&Lu, SL.(2019).Exploring nanoscale structure change of dermal tissues suffering injury by small angle X-ray scattering and transmission electron microscopy.MOLECULAR BIOLOGY REPORTS,46(1),67—76.
MLA Jiang, YZ,et al."Exploring nanoscale structure change of dermal tissues suffering injury by small angle X-ray scattering and transmission electron microscopy".MOLECULAR BIOLOGY REPORTS 46.1(2019):67—76.
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