CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
In-Situ Configuration Studies on Segmented DNA Origami Nanotubes
Zhu, BW; Guo, JY; Zhang, LX; Pan, MC; Jing, XX; Wang, LH; Liu, XG; Zuo, XL
2019
Source PublicationCHEMBIOCHEM
ISSN1439-4227
Volume20Issue:12Pages:1508—1513
Subtype期刊论文
AbstractOne-dimensional nanotubes are of considerable interest in materials and biochemical sciences. A particular desire is to create DNA nanotubes with user-defined structural features and biological relevance, which will facilitate the application of these nanotubes in the controlled release of drugs, templating of other materials into linear arrays and the construction of artificial membrane channels. However, little is known about the structures of assembled DNA nanotubes in solution. Here we report an in situ exploration of segmented DNA nanotubes, composed of multiple units with set length distributions, by using synchrotron small-angle X-ray scattering (SAXS). Through joint experimental and theoretical studies, we show that the SAXS data are highly informative in the context of heterogeneous mixtures of DNA nanotubes. The structural parameters obtained by SAXS are in good agreement with those determined by atomic force microscopy (AFM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). In particular, the SAXS data revealed important structural information on these DNA nanotubes, such as the in-solution diameters (approximate to 25 nm), which could be obtained only with difficulty by use of other methods. Our results establish SAXS as a reliable structural analysis method for long DNA nanotubes and could assist in the rational design of these structures.
KeywordSINGLE NANOSTRUCTURES FILAMENTS FLEXIBILITY TRANSPORT CHANNELS DEVICES DESIGN SHAPE
DOI10.1002/cbic.201800727
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31675
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,CAS Key Lab Interfacial P, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China;
3.Jiading Dist Cent Hosp, Shanghai 201800, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China;
5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China
Recommended Citation
GB/T 7714
Zhu, BW,Guo, JY,Zhang, LX,et al. In-Situ Configuration Studies on Segmented DNA Origami Nanotubes[J]. CHEMBIOCHEM,2019,20(12):1508—1513.
APA Zhu, BW.,Guo, JY.,Zhang, LX.,Pan, MC.,Jing, XX.,...&Zuo, XL.(2019).In-Situ Configuration Studies on Segmented DNA Origami Nanotubes.CHEMBIOCHEM,20(12),1508—1513.
MLA Zhu, BW,et al."In-Situ Configuration Studies on Segmented DNA Origami Nanotubes".CHEMBIOCHEM 20.12(2019):1508—1513.
Files in This Item: Download All
File Name/Size DocType Version Access License
In-Situ Configuratio(2644KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, BW]'s Articles
[Guo, JY]'s Articles
[Zhang, LX]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, BW]'s Articles
[Guo, JY]'s Articles
[Zhang, LX]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, BW]'s Articles
[Guo, JY]'s Articles
[Zhang, LX]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: In-Situ Configuration Studies on Segmented DNA Origami Nanotubes.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.