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Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution
Song, DK; Meng, JC; Cheng, J; Fan, Z; Chen, PY; Ruan, HF; Tu, ZY; Kang, N; Li, N; Xu, Y; Wang, XB; Shi, F; Mu, LB; Li, TF; Ren, WR; Lin, X; Zhu, J; Fang, XH; Amrein, MW; Wu, WH; Yan, LT; Lu, JH; Xia, T; Shi, Y
2019
Source PublicationNATURE MICROBIOLOGY
ISSN2058-5276
Volume4Issue:1Pages:97—+
Subtype期刊论文
AbstractBacterial quorum-sensing autoinducers are small chemicals released to control microbial community behaviours. N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas aeruginosa Lasl-LasR circuitry, triggers significant cell death in lymphocytes. We found that this molecule is incorporated into the mammalian plasma membrane and induces dissolution of eukaryotic lipid domains. This event expels tumour necrosis factor receptor 1 into the disordered lipid phase for its spontaneous trimerization without its ligand and drives caspase 3-caspase 8-mediated apoptosis. In vivo, P. aeruginosa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own better survival; conversely, blockage of caspases strongly reduces the severity of the infection. This work reveals an unknown communication method between microorganisms and the mammalian host and suggests interventions of bacterial infections by intercepting quorum-sensing signalling.
KeywordN-3-OXODODECANOYL HOMOSERINE LACTONE NF-KAPPA-B PLASMA-MEMBRANE MODEL MEMBRANES TNF-ALPHA RAFTS MOLECULES DIFFUSION ACTIVATION RECEPTORS
DOI10.1038/s41564-018-0290-8
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31780
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Tsinghua Univ, Ctr Life Sci, Inst Immunol, Dept Basic Med Sci, Beijing, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China;
3.Nankai Univ, Coll Life Sci, Dept Microbiol,Minist Educ, State Key Lab Med Chem Biol,Key Lab Mol Microbiol, Tianjin, Peoples R China;
4.Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat, MOE, Beijing, Peoples R China;
5.Univ Calgary, Snyder Inst, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada;
6.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing, Peoples R China;
7.Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA;
8.Nanjing Agr Univ, Dept Microbiol, Nanjing, Jiangsu, Peoples R China;
9.Univ Calgary, Snyder Inst, Dept Cell Biol, Calgary, AB, Canada;
10.Univ Calgary, Snyder Inst, Dept Anat, Calgary, AB, Canada
Recommended Citation
GB/T 7714
Song, DK,Meng, JC,Cheng, J,et al. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution[J]. NATURE MICROBIOLOGY,2019,4(1):97—+.
APA Song, DK.,Meng, JC.,Cheng, J.,Fan, Z.,Chen, PY.,...&Shi, Y.(2019).Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution.NATURE MICROBIOLOGY,4(1),97—+.
MLA Song, DK,et al."Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution".NATURE MICROBIOLOGY 4.1(2019):97—+.
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