CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model
Dai, LY; Huang, RH; Zhou, Y; Gu, HL; Wang, YB; Yang, CCJ; Xu, X; Ye, M; Bai, YR; Liu, YL; Li, XB; Ma, XM
2019
Source PublicationDOSE-RESPONSE
ISSN1559-3258
Volume17Issue:1Pages:
Subtype期刊论文
AbstractThe study aimed to develop a novel dose conversion platform by improving linear-quadratic (LQ) model to more accurately describe radiation response for high fraction/acute doses. This article modified the LQ model via piecewise fitting the biological dose curve using different fractionated dose and optimizing the consistency between mathematical model and experimental data to gain a more reasonable transform. That mathematical development of the LQ model further amended certain deviations of various cell curves with high doses and implied the rationality of the present model at low dose range. The modified biologically effective dose model that solved the dilemma of inaccurate LQ model had been used in comparing between hypofractionated and conventional fractioned dose. It has been verified that the calculated values are similar in the treatment of same efficacy, no matter what alpha/beta is, and provided a more rational explanation for significant differences among various hypofractionations. The equivalent uniform dose based on the subsection function could represent arbitrary inhomogeneous dose distributions including high-dose fractions, providing a foundation for the implementation of detailed evaluation of different cell dose effects.
KeywordRADIOTHERAPY SBRT SOY ISOFLAVONES LUNG-CANCER RADIOSURGERY TISSUE
DOI10.1177/1559325819828623
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31797
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Radiat Oncol, Shanghai, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China;
3.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Radiat Oncol, Shanghai, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Shanghai, Peoples R China;
5.Barnabas Hlth, Monmouth Med Ctr, Dept Radiat Oncol, Long Branch, NJ USA;
6.Soochow Univ, Affiliated Hosp 2, Dept Nucl Accid Med Emergency, Suzhou, Jiangsu, Peoples R China;
7.Soochow Univ, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect, Suzhou, Jiangsu, Peoples R China;
8.Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou, Jiangsu, Peoples R China;
9.Fujian Med Univ, Dept Radiat Oncol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China;
10.Fujian Med Univ, Coll Med Technol & Engn, Fuzhou, Fujian, Peoples R China
Recommended Citation
GB/T 7714
Dai, LY,Huang, RH,Zhou, Y,et al. Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model[J]. DOSE-RESPONSE,2019,17(1):—.
APA Dai, LY.,Huang, RH.,Zhou, Y.,Gu, HL.,Wang, YB.,...&Ma, XM.(2019).Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model.DOSE-RESPONSE,17(1),—.
MLA Dai, LY,et al."Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model".DOSE-RESPONSE 17.1(2019):—.
Files in This Item: Download All
File Name/Size DocType Version Access License
Research of Biologic(290KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dai, LY]'s Articles
[Huang, RH]'s Articles
[Zhou, Y]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dai, LY]'s Articles
[Huang, RH]'s Articles
[Zhou, Y]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dai, LY]'s Articles
[Huang, RH]'s Articles
[Zhou, Y]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Research of Biological Dose Conversion Platform Based on a Modified Linear Quadratic Model.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.