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Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion
Li, LL; Cui, YH; Lu, LY; Liu, YL; Zhu, CJ; Tian, LJ; Li, WW; Zhang, X; Cheng, H; Ma, JY; Chu, J; Tong, ZH; Yu, HQ
2019
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume53Issue:5Pages:2344—2352
Subtype期刊论文
AbstractAntagonism between heavy metal and selenium (Se) could significantly affect their biotoxicity, but little is known about the mechanisms underlying such microbial-mediated antagonistic processes as well as the formed products. In this work, we examined the cadmium (Cd)Se interactions and their fates in Caenorhabditis elegans through in vivo and in vitro analysis and elucidated the machinery of Se-stimulated Cd detoxification. Although the Se introduction induced up to 3-fold higher bioaccumulation of Cd in C. elegans than the Cd-only group, the nematode viability remained at a similar level to the Cd-only group. The relatively lower level of reactive oxygen species in the Se & Cd group confirms a significantly enhanced Cd detoxification by Se. The CdSe interaction, mediated by multiple thiols, including glutathione and phytochelatin, resulted in the formation of less toxic cadmium selenide (CdSe)/cadmium sulfide (CdS) nanoparticles. The CdSe/CdS nanoparticles were mainly distributed in the pharynx and intestine of the nematodes, and continuously excreted from the body, which also benefitted the C. elegans survival. Our findings shed new light on the microbial-mediated CdSe interactions and may facilitate an improved understanding and control of Cd biotoxicity in complicated coexposure environments.
KeywordIN-VIVO SYNTHESIS QUANTUM DOTS RAMAN-SCATTERING TOXICITY COORDINATION NANOCRYSTALS GLUTATHIONE RESPONSES GENETICS CDSE
DOI10.1021/acs.est.8b04200
Indexed BySCI
Language英语
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31808
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Univ Sci & Technol China, Dept Appl Chem, CAS Key Lab Urban Pollutant Convers, Hefei 230026, Anhui, Peoples R China;
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
Recommended Citation
GB/T 7714
Li, LL,Cui, YH,Lu, LY,et al. Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(5):2344—2352.
APA Li, LL.,Cui, YH.,Lu, LY.,Liu, YL.,Zhu, CJ.,...&Yu, HQ.(2019).Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(5),2344—2352.
MLA Li, LL,et al."Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.5(2019):2344—2352.
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