CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Translocation of tetrahedral DNA nanostructures through a solid-state nanopore
Zhao, XJ; Ma, RP; Hu, Y; Chen, XY; Dou, RF; Liu, K; Cui, CJ; Liu, HJ; Li, Q; Pan, D; Shan, XY; Wang, LH; Fan, CH; Lu, XH
2019
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:13Pages:6263—6269
Subtype期刊论文
AbstractTetrahedral DNA nanostructures (TDNs) are programmable DNA nanostructures that have great potential in bio-sensing, cell imaging and therapeutic applications. In this study, we investigate the translocation behavior of individual TDNs through solid-state nanopores. Pronounced translocation signals for TDNs are observed that are sensitive to the size of the nanostructures. TDNs bound to linear DNA molecules produce an extra signal in the ionic current traces. Statistical analysis of its relative temporal position reveals distinct features between TDNs bound to the end and those bound to the middle of the linear DNA molecules. A featured current trace for two TDNs bound to the same linear DNA molecule has also been observed. Our study demonstrates the potential of using TDNs as sensitive bio-sensors to detect specific segments of a single DNA molecule in real time, based on solid-state nanopore devices.
KeywordNUCLEIC-ACID NANOPARTICLES BIOSENSING INTERFACE TRANS LOCATION ORIGAMI PROTEIN MOLECULES VELOCITY CARRIERS
DOI10.1039/c8nr10474c
Indexed BySCI
Language英语
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31884
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China;
2.Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China;
3.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100190, Peoples R China;
4.Beijing Normal Univ, Beijing 100000, Peoples R China;
5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China;
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facill,Div Phys Biol, Shanghai 201800, Peoples R China;
8.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facill,Bioimaging Ctr, Shanghai 201800, Peoples R China;
9.Shanghai Jiao Tong Univ, Bio X Inst, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China;
10.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China;
11.Chinese Acad Sci, Ctr Excellence Topol Quantum Computat, Beijing 100190, Peoples R China;
12.Songshan Lake Mat Lab, Dongguan 523808, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhao, XJ,Ma, RP,Hu, Y,et al. Translocation of tetrahedral DNA nanostructures through a solid-state nanopore[J]. NANOSCALE,2019,11(13):6263—6269.
APA Zhao, XJ.,Ma, RP.,Hu, Y.,Chen, XY.,Dou, RF.,...&Lu, XH.(2019).Translocation of tetrahedral DNA nanostructures through a solid-state nanopore.NANOSCALE,11(13),6263—6269.
MLA Zhao, XJ,et al."Translocation of tetrahedral DNA nanostructures through a solid-state nanopore".NANOSCALE 11.13(2019):6263—6269.
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