CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
A guide to sample delivery systems for serial crystallography
Zhao, FZ; Zhang, B; Yan, EK; Sun, B; Wang, ZJ; He, JH; Yin, DC
2019
Source PublicationFEBS JOURNAL
ISSN1742-464X
Volume286Issue:22Pages:4402-4417
Subtype期刊论文
AbstractCrystallography has made a notable contribution to our knowledge of structural biology. For traditional crystallography experiments, the growth of crystals with large size and high quality is crucial, and it remains one of the bottlenecks. In recent years, the successful application of serial femtosecond crystallography (SFX) provides a new choice when only numerous microcrystals can be obtained. The intense pulsed radiation of X-ray free-electron lasers (XFELs) enables the data collection of small-sized crystals, making the size of crystals no longer a limiting factor. The ultrafast pulses of XFELs can achieve 'diffraction before destruction', which effectively avoids radiation damage and realizes diffraction near physiological temperatures. More recently, the SFX has been expanded to serial crystallography (SX) that can additionally employ synchrotron radiation as the light source. In addition to the traditional ones, these techniques provide complementary opportunities for structural determination. The development of SX experiments strongly relies on the advancement of hardware including the sample delivery system, the X-ray source, and the X-ray detector. Here, in this review, we categorize the existing sample delivery systems, summarize their progress, and propose their future prospectives.
KeywordX-RAY-DIFFRACTION ROOM-TEMPERATURE FEMTOSECOND CRYSTALLOGRAPHY PROTEIN CRYSTALLIZATION STRUCTURAL BIOLOGY MILLISECOND CRYSTALLOGRAPHY CRYSTAL-STRUCTURE RADIATION-DAMAGE DATA-COLLECTION MICROCRYSTALS
DOI10.1111/febs.15099
Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/31945
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Northwestern Polytech Univ, Sch Life Sci, 127 West Youyi Rd, Xian 710072, Shaanxi, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Appl Phys, 239 Zhangheng Rd, Shanghai 201204, Peoples R China;
3.Northwestern Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China
Recommended Citation
GB/T 7714
Zhao, FZ,Zhang, B,Yan, EK,et al. A guide to sample delivery systems for serial crystallography[J]. FEBS JOURNAL,2019,286(22):4402-4417.
APA Zhao, FZ.,Zhang, B.,Yan, EK.,Sun, B.,Wang, ZJ.,...&Yin, DC.(2019).A guide to sample delivery systems for serial crystallography.FEBS JOURNAL,286(22),4402-4417.
MLA Zhao, FZ,et al."A guide to sample delivery systems for serial crystallography".FEBS JOURNAL 286.22(2019):4402-4417.
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