CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Engineered Bacillus subtilis biofilms as living glues
Zhang, C; Huang, JF; Zhang, JC; Liu, SY; Cui, MK; An, BL; Wang, XY; Pu, JH; Zhao, TX; Fan, CH; Lu, TK; Zhong, C
2019
Source PublicationMATERIALS TODAY
ISSN1369-7021
Volume28Pages:40-48
Subtype期刊论文
AbstractThe powerful biological adhesion systems of barnacles, mussels, and other marine animals have led to bio-inspired adhesives with impressive performance characteristics. However, lacking the capacities that only cells possess (e.g., self-regeneration, environmental responsiveness, etc.), these artificial materials cannot exploit the full potential of the natural adhesive systems that inspired them. Here, we developed "functional cellular glues" made of Bacillus subtilis biofilms-tightly associated bacteria encased in an extracellular matrix-that contain both an engineered amyloid protein functionalized with a mussel foot protein and an engineered hydrophobin-like protein. We demonstrate proof-of-concept for both tunable adhesion performance via inducible enzymatic modification and for improved adhesion through metal ion-assisted curing. By conceptualizing biofilms themselves-rather than individual material components-as adhesives, we have developed an evolvable engineering platform that opens the door to make smart living glues with dynamic, self-healing, and other previously unattainable material properties.
KeywordMUSSEL FOOT PROTEINS UNDERWATER ADHESIVE SURFACE COACERVATION CHEMISTRY STICKING FIBERS PLAQUE
DOI10.1016/j.mattod.2018.12.039
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32046
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China;
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China;
7.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China;
8.MIT, Res Lab Elect, Synthet Biol Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA
Recommended Citation
GB/T 7714
Zhang, C,Huang, JF,Zhang, JC,et al. Engineered Bacillus subtilis biofilms as living glues[J]. MATERIALS TODAY,2019,28:40-48.
APA Zhang, C.,Huang, JF.,Zhang, JC.,Liu, SY.,Cui, MK.,...&Zhong, C.(2019).Engineered Bacillus subtilis biofilms as living glues.MATERIALS TODAY,28,40-48.
MLA Zhang, C,et al."Engineered Bacillus subtilis biofilms as living glues".MATERIALS TODAY 28(2019):40-48.
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