CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Structural and positional impact on DNAzyme-based electrochemical sensors for metal ions
Guo, XD; Li, M; Zhao, RT; Yang, Y; Wang, RL; Wu, F; Jia, LL; Zhang, YX; Wang, LH; Qu, ZB; Wang, F; Zhu, Y; Hao, RZ; Zhang, XL; Song, HB
2019
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
Volume21Pages:-
Subtype期刊论文
AbstractThe rapid, accurate and convenient detection of heavy metal is very important to public health. Here, we developed a DNAzyme-based electrochemical sensor for Pb2+. A DNAzyme-including and Pb2+ active probe was anchored to the biosensing interface, based on the welldefined self-assembled, three-dimensional DNA nanostructure. The results indicate that the detection performance depends on the change of distances between the methylene blue and the electrode surface. The limit of detection (LOD) could reach the concentration of 0.01 mu M Pb2+, and the signal change shows semi-logarithmic relationship with the concentration of Pb2+ from 0.01 mu M to 100 mu M. The biosensor also presents good stability and specificity to detect Pb2+ in tap or river water. This method not only provides promising approach for improving the performance of tetrahedra in detecting Pb2+, but helps deepen the understanding of tetrahedral structure design and how the position of electroactive groups affects the performance of electrochemical sensing. (C) 2019 Elsevier Inc. All rights reserved.
KeywordDNA HYBRIDIZATION SMALL MOLECULES NUCLEIC-ACIDS LEAD BIOSENSOR PB2+ NANOSTRUCTURES AMPLIFICATION FLUORESCENT PROTEINS
DOI10.1016/j.nano.2019.102035
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32219
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Acad Mil Med Sci, Acad Mil Med Sci, Beijing, Peoples R China;
2.Chinese PLA Ctr Dis Control & Prevent, Beijing, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr, Shanghai, Peoples R China;
6.Shanghai Jiao Tong Univ & Affiliated Sixth People, Joint Res Ctr Precis Med, South Campus, Shanghai, Peoples R China;
7.Southern Med Univ, Affiliated Fengxian Hosp, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Guo, XD,Li, M,Zhao, RT,et al. Structural and positional impact on DNAzyme-based electrochemical sensors for metal ions[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2019,21:-.
APA Guo, XD.,Li, M.,Zhao, RT.,Yang, Y.,Wang, RL.,...&Song, HB.(2019).Structural and positional impact on DNAzyme-based electrochemical sensors for metal ions.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,21,-.
MLA Guo, XD,et al."Structural and positional impact on DNAzyme-based electrochemical sensors for metal ions".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 21(2019):-.
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