CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch
Hao, BJ; Li, W; Zhang, S; Zhu, Y; Li, YJ; Ding, AS; Huang, XY
2020
Source PublicationPOLYMER CHEMISTRY
ISSN1759-9954
Volume11Issue:12Pages:2194-2204
Subtype期刊论文
AbstractA bioreduction-responsive nanographene oxide (NGO) based drug delivery system (DDS) for chemotherapy with a disulfide linker as a glutathione-responsive switch is designed and prepared in a facile way, which can only be activated to release original water-insoluble anticancer drugs in cancer cells. For better biocompatibility and more functionalization, this DDS was constructed through a promising platform (PEG-NGO-SH), which is based on dual-functionalized NGO with six-armed poly(ethylene glycol) on the edge and thiol groups on the basal plane. After systematic experiments, this DDS was found to exhibit a suitable lateral size (180 nm), high drug loading ratio (similar to 20 wt%), selective release (similar to 90% in 10 mM GSH), bioavailability and significant difference in cytotoxicity to normal (293T) and cancer (A549) cells. The efficacy of this DDS was proved by the effective in vitro release behavior in high GSH level medium and the significant difference in cytotoxicity against A549 and 293T cells. Thus, it was obviously verified that this bioreduction-responsive DDS triggered by GSH and its construction method using a disulfide linker as a switch on dual-functionalized NGO show potency toward tumor-targeted therapy.
KeywordDRUG-DELIVERY GRAPHENE OXIDE CARBON NANOTUBES COVALENT FUNCTIONALIZATION PACLITAXEL NANOPARTICLES CONJUGATE GRAPHITE PRODRUG
DOI10.1039/d0py00110d
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32675
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth,Key Lab Synthet & Self A, 345 Lingling Rd, Shanghai 200032, Peoples R China
2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,Div Phys Biol & Bioimagin, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Hao, BJ,Li, W,Zhang, S,et al. A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch[J]. POLYMER CHEMISTRY,2020,11(12):2194-2204.
APA Hao, BJ.,Li, W.,Zhang, S.,Zhu, Y.,Li, YJ.,...&Huang, XY.(2020).A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch.POLYMER CHEMISTRY,11(12),2194-2204.
MLA Hao, BJ,et al."A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch".POLYMER CHEMISTRY 11.12(2020):2194-2204.
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