CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo
Shen, JL; Tao, K; Gu, PL; Gui, C; Wang, D; Tan, ZY; Wang, LH; Wang, ZM; Qin, AJ; Tang, BZ; Bao, SS
2020
Source PublicationSCIENCE CHINA-CHEMISTRY
ISSN1674-7291
Volume63Issue:3Pages:393-397
Subtype期刊论文
AbstractColorectal cancer (CRC) is still a major killer, mainly due to the lack of early detection biomarker with sensitivity/specificity. Conventional histopathology is the gold standard approach in practice, but there are still some issues (false diagnosis and long waiting period). Aggregation-induced emission (AIE) is a novel photophysical phenomenon which has been widely utilized for biological imaging in vivo, including malignant cells, showing remarkable imaging contrast and enhanced emission in high concentrated state. However, it is unclear if AIE dyes can identify malignant cells specifically in vivo. A great challenge for specific labeling of malignant cells is probably ascribed to the complex compositions in tumor tissues. Herein, an AIE dye-based mitochondria-targeted histological staining strategy was employed to localize cancer and the metastatic track in the fresh colorectal cancer. This novel approach holds great potential to revolutionize the clinical diagnosis and intervention for devastating malignancy.
KeywordCELL AIEGENS
DOI10.1007/s11426-019-9677-7
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32696
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Shanghai 200240, Peoples R China
3.Univ Sydney, Charles Perkins Ctr, Bosch Inst, Discipline Pathol, Sydney, NSW, Australia
4.Univ Sydney, Charles Perkins Ctr, Sch Med Sci, Sydney, NSW, Australia
5.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Inst Mol Funct Mat,Div Biomed Engn, HKUST Jockey Club Inst Adv Study,Dept Chem,State, Hong Kong, Peoples R China
7.South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China
Recommended Citation
GB/T 7714
Shen, JL,Tao, K,Gu, PL,et al. Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo[J]. SCIENCE CHINA-CHEMISTRY,2020,63(3):393-397.
APA Shen, JL.,Tao, K.,Gu, PL.,Gui, C.,Wang, D.,...&Bao, SS.(2020).Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo.SCIENCE CHINA-CHEMISTRY,63(3),393-397.
MLA Shen, JL,et al."Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo".SCIENCE CHINA-CHEMISTRY 63.3(2020):393-397.
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