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Autophagy changes in lung tissues of mice at 30 days after carbon black-metal ion co-exposure
He, W; Peng, HZ; Ma, JF; Wang, QS; Li, AG; Zhang, JC; Kong, HT; Li, QN; Sun, YH; Zhu, Y
2020
Source PublicationCELL PROLIFERATION
ISSN0960-7722
Volume53Issue:7Pages:-
Subtype期刊论文
AbstractObjectives Accumulating studies have investigated the PM2.5-induced pulmonary toxicity, while gaps still remain in understanding its toxic mechanism. Due to its high specific surface area and adsorption capacity similar to nanoparticles, PM2.5 acts as a significant carrier of metals in air and then leads to altered toxic effects. In this study, we aimed to use CBs and Ni as model materials to investigate the autophagy changes and pulmonary toxic effects at 30 days following intratracheal instillation of CBs-Ni mixture. Materials and methods Groups of mice were instilled with 100 mu L normal saline (NS), 20 mu g CBs, and 4 mu g Ni or CBs-Ni mixture, respectively. At 7 and 30 days post-instillation, all the mice were weighed and then sacrificed. The evaluation system was composed of the following: (a) autophagy and lysosomal function assessment, (b) trace element biodistribution observation in lungs, (c) pulmonary lavage biomedical analysis, (d) lung histopathological evaluation, (e) coefficient analysis of major organs and (f) CBs-Ni interaction and cell proliferation assessment. Results We found that after CBs-Ni co-exposure, no obvious autophagy and lysosomal dysfunction or pulmonary toxicity was detected, along with complete clearance of Ni from lung tissues as well as recovery of biochemical indexes to normal range. Conclusions We conclude that the damaged autophagy and lysosomal function, as well as physiological function, was repaired at 30 days after exposure of CBs-Ni. Our findings provide a new idea for scientific assessment of the impact of fine particles on environment and human health, and useful information for the comprehensive treatment of air pollution.
KeywordULTRAFINE PARTICLES PULMONARY TOXICITY AMBIENT PM2.5 MORTALITY POLLUTION EXPOSURE FINE INFLAMMATION NANOTUBES LAMP-2
DOI10.1111/cpr.12813
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32720
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Div Phys Biol, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, 2019 Jia Luo Rd, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Bioimaging Ctr, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, 2019 Jia Luo Rd, Shanghai 201800, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai, Peoples R China
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GB/T 7714
He, W,Peng, HZ,Ma, JF,et al. Autophagy changes in lung tissues of mice at 30 days after carbon black-metal ion co-exposure[J]. CELL PROLIFERATION,2020,53(7):-.
APA He, W.,Peng, HZ.,Ma, JF.,Wang, QS.,Li, AG.,...&Zhu, Y.(2020).Autophagy changes in lung tissues of mice at 30 days after carbon black-metal ion co-exposure.CELL PROLIFERATION,53(7),-.
MLA He, W,et al."Autophagy changes in lung tissues of mice at 30 days after carbon black-metal ion co-exposure".CELL PROLIFERATION 53.7(2020):-.
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