CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity
Shen, ZW; Guo, Z; Zhou, LM; Wang, YJ; Zhang, JJ; Hu, J; Zhang, Y
2020
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume8Issue:7Pages:2031-2039
Subtype期刊论文
AbstractAntimicrobial peptides (AMPs) as biocides are of great interest because they have the ability to combat antibiotic resistance. Normally, natural AMPs need to be rationally designed or modified for practical use as an antibiotic. Here, a novel AMP, termed FF8, which is a cationic octapeptide composed of arginine, lysine, and phenylalanine, was designed. The FF8 was found to self-assemble into nanofibers when induced by a negatively charged lipid membrane or pH is above 9.4. The fibers on the membrane broke the lipid membrane, forming pores and significantly reducing its fluidity. FF8 also exhibited enhanced antibacterial activity by significantly increasing the permeability of the inner and outer membranes of Escherichia coli (E. coli) and maintaining the pores of the inner membrane of cells, which caused continuous membrane leakage. Because of its high antibacterial activity, cytocompatibility, and cost-effectiveness, FF8 is a promising antibacterial material.
KeywordAMYLOID-LIKE FIBRILS MECHANICAL-PROPERTIES MEMBRANE NANOPARTICLES FIELD
DOI10.1039/c9bm01785b
Indexed BySCI ; EI
Language英语
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32731
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100019, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China
Recommended Citation
GB/T 7714
Shen, ZW,Guo, Z,Zhou, LM,et al. Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity[J]. BIOMATERIALS SCIENCE,2020,8(7):2031-2039.
APA Shen, ZW.,Guo, Z.,Zhou, LM.,Wang, YJ.,Zhang, JJ.,...&Zhang, Y.(2020).Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity.BIOMATERIALS SCIENCE,8(7),2031-2039.
MLA Shen, ZW,et al."Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity".BIOMATERIALS SCIENCE 8.7(2020):2031-2039.
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