CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA Framework-Based Topological Cell Sorters
Yin, FF; Li, M; Mao, XH; Li, F; Xiang, XL; Li, Q; Wang, LH; Zuo, XL; Fan, CH; Zhu, Y
2020
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume59Issue:26Pages:10406-10410
Subtype期刊论文
AbstractMolecular recognition in cell biological process is characterized with specific locks-and-keys interactions between ligands and receptors, which are ubiquitously distributed on cell membrane with topological clustering. Few topologically-engineered ligand systems enable the exploration of the binding strength between ligand-receptor topological organization. Herein, we generate topologically controlled ligands by developing a family of tetrahedral DNA frameworks (TDFs), so the multiple ligands are stoichiometrically and topologically arranged. This topological control of multiple ligands changes the nature of the molecular recognition by inducing the receptor clustering, so the binding strength is significantly improved (ca. 10-fold). The precise engineering of topological complexes formed by the TDFs are readily translated into effective binding control for cell patterning and binding strength control of cells for cell sorting. This work paves the way for the development of versatile design of topological ligands.
KeywordNANOSTRUCTURES INTEGRIN FORCES TCR
DOI10.1002/anie.202002020
Indexed BySCI ; EI
Language英语
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32803
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200127, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
6.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China
Recommended Citation
GB/T 7714
Yin, FF,Li, M,Mao, XH,et al. DNA Framework-Based Topological Cell Sorters[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(26):10406-10410.
APA Yin, FF.,Li, M.,Mao, XH.,Li, F.,Xiang, XL.,...&Zhu, Y.(2020).DNA Framework-Based Topological Cell Sorters.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(26),10406-10410.
MLA Yin, FF,et al."DNA Framework-Based Topological Cell Sorters".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.26(2020):10406-10410.
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