CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA Framework-Based Topological Cell Sorters
Yin, FF; Li, M; Mao, XH; Li, F; Xiang, XL; Li, Q; Wang, LH; Zuo, XL; Fan, CH; Zhu, Y
AbstractMolecular recognition in cell biological process is characterized with specific locks-and-keys interactions between ligands and receptors, which are ubiquitously distributed on cell membrane with topological clustering. Few topologically-engineered ligand systems enable the exploration of the binding strength between ligand-receptor topological organization. Herein, we generate topologically controlled ligands by developing a family of tetrahedral DNA frameworks (TDFs), so the multiple ligands are stoichiometrically and topologically arranged. This topological control of multiple ligands changes the nature of the molecular recognition by inducing the receptor clustering, so the binding strength is significantly improved (ca. 10-fold). The precise engineering of topological complexes formed by the TDFs are readily translated into effective binding control for cell patterning and binding strength control of cells for cell sorting. This work paves the way for the development of versatile design of topological ligands.
Indexed BySCI ; EI
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200127, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
6.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China
Recommended Citation
GB/T 7714
Yin, FF,Li, M,Mao, XH,et al. DNA Framework-Based Topological Cell Sorters[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(26):10406-10410.
APA Yin, FF.,Li, M.,Mao, XH.,Li, F.,Xiang, XL.,...&Zhu, Y.(2020).DNA Framework-Based Topological Cell Sorters.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(26),10406-10410.
MLA Yin, FF,et al."DNA Framework-Based Topological Cell Sorters".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.26(2020):10406-10410.
Files in This Item: Download All
File Name/Size DocType Version Access License
DNA Framework-Based (1762KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yin, FF]'s Articles
[Li, M]'s Articles
[Mao, XH]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yin, FF]'s Articles
[Li, M]'s Articles
[Mao, XH]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yin, FF]'s Articles
[Li, M]'s Articles
[Mao, XH]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: DNA Framework-Based Topological Cell Sorters.pdf
Format: Adobe PDF
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.