CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA Framework-Encoded Mineralization of Calcium Phosphate
Liu, XG; Jing, XX; Liu, P; Pan, MC; Liu, Z; Dai, XP; Lin, JP; Li, Q; Wang, F; Yang, SC; Wang, LH; Fan, CH
2020
Source PublicationCHEM
ISSN2451-9294
Volume6Issue:2Pages:472-485
Subtype期刊论文
AbstractNature has evolved unique strategies to generate delicate biominerals at various length scales with genetically encoded protein scaffolds, Nevertheless, the ability to design programmable biomimetic mineralized nanostructures remains limited. Here, we report that self-assembled DNA frameworks can encode the nanoscale mineralization of calcium phosphate (CaP) with precision and versatility. We establish that the size and shape of DNA-CaP nanostructures are programmed by the structural information encoded within DNA sequences and the electrostatic interactions between DNA phosphate backbone and mineral counterparts. The generality of this strategy is verified by using two- and three-dimensional DNA framework ranging from similar to 10 to similar to 100 nm. We further find that CaP mineralization-solidified DNA framework functions as a sustainable nanoagent for live-cell delivery of drugs. These findings open a new avenue for nanoscale mineralization with unprecedented sophisticated architectures for versatile applications.
KeywordPARTICLE MESH EWALD HYDROXYAPATITE NANOSCALE DELIVERY NANOSTRUCTURES NANOPARTICLES DRUG
DOI10.1016/j.chempr.2019.12.003
Indexed BySCI
Language英语
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32804
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 201240, Peoples R China
2.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 201240, Peoples R China
3.Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China
4.Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China
5.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Biodesign Ctr, Tianjin 300308, Peoples R China
6.Chinese Acad Sci, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,Div Phys Biol, Shanghai 201800, Peoples R China
7.Case Western Reserve Univ, Ctr Prote, 10900 Euclid Ave, Cleveland, OH 44106 USA
8.Case Western Reserve Univ, Dept Nutr, 10900 Euclid Ave, Cleveland, OH 44106 USA
Recommended Citation
GB/T 7714
Liu, XG,Jing, XX,Liu, P,et al. DNA Framework-Encoded Mineralization of Calcium Phosphate[J]. CHEM,2020,6(2):472-485.
APA Liu, XG.,Jing, XX.,Liu, P.,Pan, MC.,Liu, Z.,...&Fan, CH.(2020).DNA Framework-Encoded Mineralization of Calcium Phosphate.CHEM,6(2),472-485.
MLA Liu, XG,et al."DNA Framework-Encoded Mineralization of Calcium Phosphate".CHEM 6.2(2020):472-485.
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