CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA Nanostructures in the Study of Molecular Interactions
Li, H; Hao, YY; Wang, F; Wang, LH; Liu, G
AbstractExploring molecular interaction mechanisms is vital for a better understanding of life activities. In recent years, with the development of DNA nanotechnology, researchers have been using DNA nanostructures to study molecular interactions. Numerous progresses have been made on molecular interaction mechanisms using DNA nanostructures. With high programmability and addressability of DNA nanostructures, the system to be observed could be located on DNA nanostructures through different strategies such as DNA hybridization and covalent interactions. The spatial arrangement, molecule type, and the number of target molecules can be precisely controlled. Thus, DNA nanostructures offer an excellent template for observing molecular interactions. With the designability and high rigidity, DNA nanostructures could be utilized as frames with certain mechanical properties. By spatially organizing anchored molecules, nanoscale microenvironment could also be regulated on the platform of DNA nanostructures. In addition, DNA nanotechnology could be combined with various single-molecule techniques such as fluorescent imaging, atomic force microscopy, allowing single-molecule study with DNA nanostructures. In this review, we provide an overview of the construction of observing platforms with DNA nanostructures and the applications of DNA nanostructures in the study of molecular interactions. Finally, we summarize and prospect the development of DNA nanotechnology in this field.
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Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
4.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
5.Shanghai Inst Measurement & Testing Technol, Div Chem, Lab Biometrol, Shanghai 201203, Peoples R China
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GB/T 7714
Li, H,Hao, YY,Wang, F,et al. DNA Nanostructures in the Study of Molecular Interactions[J]. ACTA POLYMERICA SINICA,2020,51(7):728-737.
APA Li, H,Hao, YY,Wang, F,Wang, LH,&Liu, G.(2020).DNA Nanostructures in the Study of Molecular Interactions.ACTA POLYMERICA SINICA,51(7),728-737.
MLA Li, H,et al."DNA Nanostructures in the Study of Molecular Interactions".ACTA POLYMERICA SINICA 51.7(2020):728-737.
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