CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery
Ge, ZL; Guo, LJ; Wu, GQ; Li, J; Sun, YL; Hou, YQ; Shi, JY; Song, SP; Wang, LH; Fan, CH; Lu, H; Li, Q
2020
Source PublicationSMALL
ISSN1613-6810
Volume16Issue:16Pages:-
Subtype期刊论文
AbstractEffective drug delivery systems that can systematically and selectively transport payloads to disease cells remain a challenge. Here, a targeting ligand-modified DNA origami nanostructure (DON) as an antibody-drug conjugate (ADC)-like carrier for targeted prostate cancer therapy is reported. Specifically, DON of six helical bundles is modified with a ligand 2-[3-(1,3-dicarboxy propyl)-ureido] pentanedioic acid (DUPA) against prostate-specific membrane antigen (PSMA), to serve as the antibody for drug conjugation in ADC. Doxorubicin (Dox) is then loaded to DON through intercalation to dsDNA. This platform features in spatially controllable organization of targeting ligands and high drug loading capacity. With this nanocomposite, selective delivery of Dox to the PSMA+ cancer cell line LNCaP is readily achieved. The consequent therapeutic efficacy is critically dependent on the numbers of targeting ligand assembled on DON. This target-specific and biocompatible drug delivery platform with high maximum tolerated doses shows immense potential for developing novel nanomedicine.
KeywordTRASTUZUMAB EMTANSINE BRENTUXIMAB VEDOTIN CANCER-THERAPY ANTIBODY NANOSTRUCTURES NANOROBOT TRANSPORT EFFICACY IMPROVES SYSTEM
DOI10.1002/smll.201904857
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32810
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China
2.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, Div Phys Biol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
4.Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
5.Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn, Key Lab Polymer Chem & Phys,Minist Educ,Coll Chem, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Ge, ZL,Guo, LJ,Wu, GQ,et al. DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery[J]. SMALL,2020,16(16):-.
APA Ge, ZL.,Guo, LJ.,Wu, GQ.,Li, J.,Sun, YL.,...&Li, Q.(2020).DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery.SMALL,16(16),-.
MLA Ge, ZL,et al."DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery".SMALL 16.16(2020):-.
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