CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer
Shang, Haijiao1,2,3; Pu, Yuehu1,2; Chen, Zhiling4; Wang, Xuetao5; Yuan, Cuiyun6; Jin, Xiance7; Liu, Chenbin6
2020
Source PublicationACS Sensors
ISSN2379-3694
Subtype期刊论文
AbstractThe increase of proton beam number might provide higher degrees of freedom in the optimization of intensity-modulated proton therapy planning. In this study, we aimed to quantitatively explore the potential benefits of the increased beam number, including dose volume histogram (DVH), linear energy transfer volume histogram, and DVH bandwidth metrics. Twelve patients with lung cancer are retrospectively selected. Four plans were created based on internal target volume (ITV) robust optimization for each patient using the RayStation treatment planning system. Four plans were generated using different numbers (three, five, seven, and nine) of evenly separated coplanar beams. The three-beam plan was considered as the reference plan. Biologically equivalent doses were calculated using both constant relative biological effectiveness (RBE) and variable RBE models, respectively. To evaluate plan quality, DVH metrics in the target [ITV: D2%, CI, HI] and organs-at-risk [Lung: V5Gy[RBE], V20Gy[RBE], V30Gy[RBE]; Heart D2%; Spinal cord D2%] were calculated using both RBE models. To evaluate LET distributions, LET volume histogram metrics [ITV LETmean and LET2%; Lung LETmean and LET2%; Heart LET2%; Spinal cord LET2%] were quantified. To evaluate plan robustness, the metrics using DVH bandwidth [ITV: D2%, D99%; Lung: V5Gy[RBE], V20Gy[RBE], V30Gy[RBE]; Heart D2%; Spinal cord D2%] were also reported. For plan quality, the increase of proton beam number resulted in fewer target hot spots, improved target dose conformity, improved target dose homogeneity, lower median-dose lung volume, and fewer hot spots in spinal cord. As to LET distributions, target mean LET increased significantly as the beam number increased to seven or more. Lung LET hot spots were significantly reduced with the increase of proton beams. With respect to plan robustness, the robustness of target dose coverage, target hot spots, and low-dose lung volume were improved, while the robustness of heart hot spots became worse as the beam number increased to nine. The robustness of cord hot spots became worse using five and seven beams compared to that using three beams. As the proton beam number increased, plan quality and LET distributions were comparable or significantly improved. The robustness of target dose coverage, target dose hot spots, and low-dose lung volume were significantly improved. ©
KeywordProton beam therapy Bandwidth Biological organs Degrees of freedom (mechanics) Diseases Energy transfer Graphic methods Heart Optimization Proton beams Quality control Dose volume histograms Intensity modulated proton therapies Internal target volume Linear energy transfer Potential benefits Relative biological effectiveness Robust optimization Treatment planning systems
DOI10.1021/acssensors.0c01879
Indexed ByEI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32921
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai; 201800, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China;
3.RaySearch China, Shanghai; 200120, China;
4.Shanghai Advanced Research Institute, Chinese Academy Sciences, Shanghai; 201210, China;
5.Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu; 610041, China;
6.Department of Radiation Oncology, Natl. Cancer Ctr./National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen; 518116, China;
7.Department of Radiation and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou; 32500, China
Recommended Citation
GB/T 7714
Shang, Haijiao,Pu, Yuehu,Chen, Zhiling,et al. Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer[J]. ACS Sensors,2020.
APA Shang, Haijiao.,Pu, Yuehu.,Chen, Zhiling.,Wang, Xuetao.,Yuan, Cuiyun.,...&Liu, Chenbin.(2020).Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer.ACS Sensors.
MLA Shang, Haijiao,et al."Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer".ACS Sensors (2020).
Files in This Item: Download All
File Name/Size DocType Version Access License
Impact of Multiple B(8993KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shang, Haijiao]'s Articles
[Pu, Yuehu]'s Articles
[Chen, Zhiling]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shang, Haijiao]'s Articles
[Pu, Yuehu]'s Articles
[Chen, Zhiling]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shang, Haijiao]'s Articles
[Pu, Yuehu]'s Articles
[Chen, Zhiling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.