CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation
Ren, Yue1; Wang, Zi-Yang1; Wei, Xin1; Xu, Lu2; Gul, Rizwan M.3; Huang, Shi-Shu4; Xu, Jia-Zhuang1; Li, Zhong-Ming1
2020
Source PublicationACS Applied Bio Materials
ISSN2576-6422
Volume3Issue:1Pages:547-553
Subtype期刊论文
AbstractOxidative degradation of ultrahigh molecular weight polyethylene (UHMWPE) bearings is one of the main factors that deteriorates their mechanical properties and abrasive wear resistance, which further results in the failure of total joint replacements. Absorption and diffusion of synovial fluids have been considered as causes of the oxidation of UHMWPE bearings. However, the role of synovial fluids in oxidation of UHMWPE remains elusive. In this work, we aimed to reveal the oxidation mechanism of UHMWPE joints with respect to squalene (a representative component of the synovial fluid). The UHMWPE doped in squalene showed slight oxidation, while severe oxidation was observed when squalene doped UHMWPE was exposed to oxygen atmosphere. Squalene manifested lipid peroxidation with notable oxidation products and oxygen-derived free radicals during thermo-oxidative aging. Lipid peroxidation was deduced to follow two routes including autoxidation and thermal oxidation. The aggressive free radicals of squalene abstracted hydrogen atoms from the UHMWPE chains, initiating the oxidation of UHMWPE artificial joints. These findings not only provide evidence for comprehending the process of squalene-induced UHMWPE oxidation but also are instructive to develop highly oxidative-resistant UHMWPE. Copyright © 2019 American Chemical Society.
KeywordUltrahigh molecular weight polyethylenes Aliphatic compounds Arthroplasty Atoms Bearings (machine parts) Diffusion in liquids Free radical reactions Free radicals Joint prostheses Lipids Molecular weight Oxidative stress Oxygen Thermooxidation Wear resistance Accelerated aging Lipid peroxidation Oxidation mechanisms Oxidation products Oxidative degradation squalene Thermo oxidative aging Total joint replacement
DOI10.1021/acsabm.9b00960
Indexed ByEI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32943
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu; 610065, China;
2.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai; 201899, China;
3.Department of Mechanical Engineering, University of Engineering and Technology, Peshawar; 25120, Pakistan;
4.Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu; 610041, China
Recommended Citation
GB/T 7714
Ren, Yue,Wang, Zi-Yang,Wei, Xin,et al. Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation[J]. ACS Applied Bio Materials,2020,3(1):547-553.
APA Ren, Yue.,Wang, Zi-Yang.,Wei, Xin.,Xu, Lu.,Gul, Rizwan M..,...&Li, Zhong-Ming.(2020).Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation.ACS Applied Bio Materials,3(1),547-553.
MLA Ren, Yue,et al."Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation".ACS Applied Bio Materials 3.1(2020):547-553.
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