CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions
Lei, XL; Ma, HS; Fang, HP
2020
Source PublicationNANOSCALE
ISSN2040-3364
Volume12Issue:12Pages:6699-6707
Subtype期刊论文
AbstractDNA/GO functional structures have been widely used in biosensors, biomedicine and materials science. However, most studies about DNA/GO functional structures do not take into account the coexistence of both large unoxidized and oxidized regions on GO sheets. This special local structure provides the boundary region, which is the junction area between unoxidized and oxidized regions, and exhibits a special amphiphilic property of the GO sheets. Here based on molecular dynamics simulations, our results predict that the adsorption efficiency of long strand ssDNA molecules adsorbed on GO is 43%. Further analysis has shown that the ssDNA adsorption behaviors on the GO surface are more likely to start in the boundary region, even for 20 mer ssDNA molecules. Looking into the adsorption dynamic process we can see that the hydrogen bonds between ssDNA and GO are very active and easily broken and formed, especially for the boundary region of the GO surface, resulting in easy capture and adsorption of the ssDNA molecules on this region. The result provides insightful understanding of the adsorption behavior of ssDNA molecules on this amphiphilic GO surface and is helpful in the design of DNA/GO functional structure-based biosensors.
KeywordSINGLE-STRANDED-DNA MOLECULAR-DYNAMICS CARBON NANOTUBE ATOMIC-STRUCTURE MEMBRANES BINDING SURFACE FUNCTIONALIZATION NANOCOMPOSITES SIMULATIONS
DOI10.1039/c9nr10170e
Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/32977
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.East China Univ Sci & Technol, Dept Phys, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, POB 800-204, Shanghai 201800, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, POB 800-204, Shanghai 201800, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Lei, XL,Ma, HS,Fang, HP. Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions[J]. NANOSCALE,2020,12(12):6699-6707.
APA Lei, XL,Ma, HS,&Fang, HP.(2020).Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions.NANOSCALE,12(12),6699-6707.
MLA Lei, XL,et al."Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions".NANOSCALE 12.12(2020):6699-6707.
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