CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Meta-DNA structures
Yao, GB; Zhang, F; Wang, F; Peng, TH; Liu, H; Poppleton, E; Sulc, P; Jiang, SX; Liu, L; Gong, C; Jing, XX; Liu, XG; Wang, LH; Liu, Y; Fan, CH; Yan, H
Source PublicationNATURE CHEMISTRY
AbstractDNA origami has emerged as a highly programmable method to construct customized objects and functional devices in the 10-100 nm scale. Scaling up the size of the DNA origami would enable many potential applications, which include metamaterial construction and surface-based biophysical assays. Here we demonstrate that a six-helix bundle DNA origami nanostructure in the submicrometre scale (meta-DNA) could be used as a magnified analogue of single-stranded DNA, and that two meta-DNAs that contain complementary 'meta-base pairs' can form double helices with programmed handedness and helical pitches. By mimicking the molecular behaviours of DNA strands and their assembly strategies, we used meta-DNA building blocks to form diverse and complex structures on the micrometre scale. Using meta-DNA building blocks, we constructed a series of DNA architectures on a submicrometre-to-micrometre scale, which include meta-multi-arm junctions, three-dimensional (3D) polyhedrons, and various 2D/3D lattices. We also demonstrated a hierarchical strand-displacement reaction on meta-DNA to transfer the dynamic features of DNA into the meta-DNA. This meta-DNA self-assembly concept may transform the microscopic world of structural DNA nanotechnology.
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Affiliation1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Natl Ctr Translat Med, Shanghai, Peoples R China
3.Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA
4.Arizona State Univ, Ctr Mol Design & Biomimet, Biodesign Inst, Tempe, AZ 85287 USA
5.Rutgers State Univ, Dept Chem, Newark, NJ USA
6.Southern Med Univ, Affiliated Fengxian Hosp, Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Joint Res Ctr Precis Med, South Campus, Shanghai, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol, Shanghai, Peoples R China
8.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai, Peoples R China
9.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai, Peoples R China
10.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Nucle Acids Chem & Nanomed, Inst Mol Med,Renji Hosp, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Yao, GB,Zhang, F,Wang, F,et al. Meta-DNA structures[J]. NATURE CHEMISTRY,2020,12(11):1067-+.
APA Yao, GB.,Zhang, F.,Wang, F.,Peng, TH.,Liu, H.,...&Yan, H.(2020).Meta-DNA structures.NATURE CHEMISTRY,12(11),1067-+.
MLA Yao, GB,et al."Meta-DNA structures".NATURE CHEMISTRY 12.11(2020):1067-+.
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