CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer
Xing, Y; Jiang, ZQ; Akakuru, OU; He, Y; Li, AG; Li, J; Wu, AG
2020
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume189Pages:-
Subtype期刊论文
AbstractEpithelial ovarian cancer is still the leading cause of death in gynecology due to its resistance to platinum-based first-line chemotherapeutic drugs. The utilization of mitochondria-targeted drugs has become an important direction in anti-tumor drug research and development. In this work, cisplatin (DDP)-loaded ZIF-90 with mitochondrial-targeting was synthesized at room temperature with a high drug loading (11.7 %, calculated based on Pt content). The ZIF-90@DDP showed high cellular uptake and less toxicity in both non- and DDP-resistant ovarian cancer cells with effective pH- and ATP-responsive drug release. Both mitochondria-targeting and responsive drug release could increase the drug concentration in mitochondria of drug-resistant cancer cells to reverse such resistance. Conclusively, the mitochondria-targeting ZIF-90@DDP with high drug loading could trigger responsive drug release in mitochondria of epithelial ovarian cancer cells, inhibit DPP-resistant epithelial ovarian cancer cells, and reverse drug resistance.
KeywordMETAL-ORGANIC FRAMEWORKS ONE-POT SYNTHESIS ZIF-90 MEMBRANE FAVORABLE BIOCOMPATIBILITY DRUG-RESISTANCE DELIVERY NANOPARTICLES SELECTIVITY DOXORUBICIN ATP
DOI10.1016/j.colsurfb.2020.110837
Indexed BySCI ; EI
Language英语
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33012
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Ningbo First Hosp, Dept Gynecol, Ningbo 315010, Peoples R China
2.Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Cixi Inst Biomed, Ningbo 315201, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
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GB/T 7714
Xing, Y,Jiang, ZQ,Akakuru, OU,et al. Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,189:-.
APA Xing, Y.,Jiang, ZQ.,Akakuru, OU.,He, Y.,Li, AG.,...&Wu, AG.(2020).Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer.COLLOIDS AND SURFACES B-BIOINTERFACES,189,-.
MLA Xing, Y,et al."Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer".COLLOIDS AND SURFACES B-BIOINTERFACES 189(2020):-.
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